2. Gene
  3. LAPTM4A - lysosomal protein transmembrane 4 alpha Gene

LAPTM4A - lysosomal protein transmembrane 4 alpha Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MBNT; Mtrp; LAPTM4; HUMORF13

Gene ID: 9741 | Gene type: protein coding

About LAPTM4A

Cytogenetic location: 2p24.1 Genomic coordinates (GRCh38): 2:20,032,650-20,051,628 (from NCBI)

This gene has 2 transcripts (splice variants), 211 orthologues and 2 paralogues. Ubiquitous expression in endometrium (RPKM 245.2), testis (RPKM 209.5) and 25 other tissues.

Summary

This gene encodes a protein that has four predicted transmembrane domains. The function of this gene has not yet been determined; however, studies in the mouse homolog suggest a role in the transport of small molecules across endosomal and lysosomal membranes. [provided by RefSeq, Jul 2008]

LAPTM4A Products(1)

mRNA Protein Name
NM_014713.5 NP_055528.1 lysosomal-associated transmembrane protein 4A
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21224396 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
10942595 GOA
located in late endosome membrane IDA
IDA: Inferred from direct assay
22096579 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
22096579 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LAPTM4A Protein Structure

Mtp

Mtp: Golgi 4-transmembrane spanning transporter (37 - 233)

  • 0
  • 100
  • 200
  • 233 a.a.
Protein Preferred Names Protein Names

lysosomal-associated transmembrane protein 4A

golgi 4-transmembrane-spanning transporter MTP

LAPTM4A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
LAPTM4A Q15012 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra
LAPTM4A Q15012 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra
LAPTM4A Q15012 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra
LAPTM4A Q15012 TMED8 Homo sapiens Q6PL24
Y2H Prey Pooling
32296183
Intra
LAPTM4A Q15012 TMED8 Homo sapiens Q6PL24
Validated Y2H
32296183
Intra
LAPTM4A Q15012 TMED8 Homo sapiens Q6PL24
Y2H Array
32296183
Intra
LAPTM4A Q15012 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra
LAPTM4A Q15012 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra
LAPTM4A Q15012 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
LAPTM4A Q15012 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
LAPTM4A Q15012 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
LAPTM4A Q15012 EEF1D Homo sapiens P29692-2
Validated Y2H
32814053
Intra
LAPTM4A Q15012 EEF1D Homo sapiens P29692-2
Y2H Array
32814053
Intra
LAPTM4A Q15012 EEF1D Homo sapiens P29692-2
Y2H Pooling
32814053
Intra
LAPTM4A Q15012 UQCRB Homo sapiens P14927
Y2H Array
32814053
Intra
LAPTM4A Q15012 UQCRB Homo sapiens P14927
Y2H Pooling
32814053
Intra
LAPTM4A Q15012 UQCRB Homo sapiens P14927
Validated Y2H
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Myofascial Pain Syndrome

Myofascial Pain Syndromes

Myofascial Pain Dysfunction Syndrome

Fibromyalgia
Patellofemoral Pain Syndrome
Plantar Fasciitis

Fasciitis, Plantar
Facial Neuralgia
Shoulder Impingement Syndrome

Impingement Syndrome Of Shoulder Region

Subacromial Impingement
Frozen Shoulder

Adhesive Capsulitis Of Shoulder

Bursitis

Adhesions-Capsulitis,Shoulder

Pericapsulitis Of Shoulder

Duplay Bursitis

Adhesive Shoulder Peritendinitis

Subscapular Adhesion

Shoulder Adhesion

Adhesive Enthesopathy Of Shoulder Region

Adhesive Peritendinitis

Adhesive Shoulder Tenosynovitis

Duplay Periarthritis

Adhesive Shoulder Tendinitis
Epicondylitis

Tennis Elbow

Lateral Epicondylitis

Golfer'S Elbow

Medial Epicondylitis

Andrel Epicondylitis

Archer'S Elbow

Hockey Elbow

Shooter'S Elbow
Heel Spur

Calcaneal Spur
Bursitis

Bursitis, Not Otherwise Specified

Inflammation Of Bursa
Urethral Syndrome

Urethral Disease

Urethral Diseases

Urethra Disease

Abnormality Of The Urethra

Urethral Disorders
Somatoform Disorder

Physiological Malfunction Arising From Mental Factor

Psychosomatic Disorder

Psychophysiologic Disorders
Spondylosis

Lumbar Spondylosis With Myelopathy

Lumbosacral Spondylosis Without Myelopathy

Spondylogenic Compression Of Lumbar Spinal Cord

Spondylogenic Compression Of Thoracic Spinal Cord

Spondylosis With Myelopathy

Thoracic Or Lumbar Spondylosis With Myelopathy
Radiculopathy

Pinched Nerve

Nerve Root Disorder

Radiculopathy, Site Unspecified

Radicular Neuropathy

Radicular Syndrome

Radicular Pain

Radiculitis

Radiculitis Nos

Spinal Root Pain

Nerve Root Neuritis

Radiculopathy In Spondylosis
De Quervain Disease

Radial Styloid Tenosynovitis

Tenosynovitis, De Quervain'S

De Quervain'S Disease

Tenosynovitis Of Radial Styloid Process

Stenosans Tenosynovitis
Paine Syndrome

Pain Disorder

Pain

Microcephaly With Spastic Diplegia

Pain Syndrome
Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07521 LAPTM4A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris LAPTM4A VGNC VGNC:42583
Mus musculus LAPTM4A MGD MGI:108017
Rattus norvegicus LAPTM4A RGD RGD:735179
Macaca mulatta LAPTM4A VGNC VGNC:74272
Bos taurus LAPTM4A VGNC VGNC:30787