ARHGEF11 - Rho guanine nucleotide exchange factor 11 Gene

Homo sapiens

Also known as GTRAP48; PDZ-RHOGEF

Gene ID: 9826 | Gene type: protein coding

About ARHGEF11

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:156,934,840-157,046,903 (from NCBI)

This gene has 7 transcripts (splice variants), 199 orthologues and 8 paralogues. Ubiquitous expression in testis (RPKM 13.2), brain (RPKM 7.8) and 25 other tissues.

Summary

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin Cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

ARHGEF11 Products(4)

mRNA	Protein	Name
NM_001377418.1	NP_001364347.1	rho guanine nucleotide exchange factor 11 isoform 3
NM_001377419.1	NP_001364348.1	rho guanine nucleotide exchange factor 11 isoform 4
NM_014784.4	NP_055599.1	rho guanine nucleotide exchange factor 11 isoform 1
NM_198236.3	NP_937879.1	rho guanine nucleotide exchange factor 11 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor binding	IDA IDA: Inferred from direct assay	15755723	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10026210	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	15755723	GOA
involved in Rho protein signal transduction	IDA IDA: Inferred from direct assay	10026210	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10026210	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15755723	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGEF11 Protein Structure

PDZ

RGS-like

RhoGEF

0
300
600
900
1200
1522 a.a.

Protein Preferred Names

Protein Names

rho guanine nucleotide exchange factor 11

Rho guanine exchange factor (GEF) 11

ARHGEF11 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ARHGEF11	O15085	NCK1	Homo sapiens	P16333	Peptide Array	17474147
Intra	ARHGEF11	O15085	RHOA	Homo sapiens	P61586	GMS	15530360
Intra	ARHGEF11	O15085	RHOA	Homo sapiens	P61586	GDP/GTP Exchange	15530360
Intra	ARHGEF11	O15085	RHOA	Homo sapiens	P61586	Anti Tag CoIP	20300064
Cross	ARHGEF11	O15085	espH	Escherichia coli O157:H7	Q7DB74	Anti Tag CoIP	20300064
Intra	ARHGEF11	O15085	CRK	Homo sapiens	P46108	Peptide Array	17474147

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Fetal Macrosomia

Cone-Rod Dystrophy 8

CORD8

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00948	ARHGEF11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ARHGEF11	MGD	MGI:2441869
Rattus norvegicus	ARHGEF11	RGD	RGD:619705
Macaca mulatta	ARHGEF11	VGNC	VGNC:69829
Bos taurus	ARHGEF11	VGNC	VGNC:54878
Felis catus	ARHGEF11	VGNC	VGNC:59898
Canis familiaris	ARHGEF11	VGNC	VGNC:38074

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