TOMM70 - translocase of outer mitochondrial membrane 70 Gene

Homo sapiens

Also known as Tom70; TOMM70A

Gene ID: 9868 | Gene type: protein coding

About TOMM70

Cytogenetic location: 3q12.2 Genomic coordinates (GRCh38): 3:100,363,431-100,401,089 (from NCBI)

This gene has 3 transcripts (splice variants), 203 orthologues and 18 paralogues. Ubiquitous expression in brain (RPKM 23.1), thyroid (RPKM 20.6) and 25 other tissues.

Summary

This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins. The protein interacts with the SARS-CoV and SARS-Cov-2 ORF9b proteins. [provided by RefSeq, Dec 2021]

TOMM70 Products(1)

mRNA	Protein	Name
NM_014820.5	NP_055635.3	mitochondrial import receptor subunit TOM70

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	20628368	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12526792	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of innate immune response	IDA IDA: Inferred from direct assay	20628368	GOA
involved in cellular response to virus	IDA IDA: Inferred from direct assay	25609812	GOA
involved in positive regulation of defense response to virus by host	IDA IDA: Inferred from direct assay	20628368	GOA
involved in positive regulation of interferon-beta production	IDA IDA: Inferred from direct assay	20628368	GOA
involved in regulation of apoptotic process	IDA IDA: Inferred from direct assay	25609812	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in mitochondrial membrane	IDA IDA: Inferred from direct assay	20628368	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	20531390	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TOMM70 Protein Structure

TPR_11

TPR_8

0
100
200
300
400
500
608 a.a.

Protein Preferred Names

Protein Names

mitochondrial import receptor subunit TOM70

mitochondrial precursor proteins import receptor

TOMM70 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	TOMM70	O94826	orf9b_sars2	SARS-CoV-2	P0DTD2	Proximity Labelling	34232536
Cross	TOMM70	O94826	orf9b_sars2	SARS-CoV-2	P0DTD2	Solution Sedimentation	33990585
Cross	TOMM70	O94826	orf9b_sars2	SARS-CoV-2	P0DTD2	X-Ray Diffraction	33990585
Cross	TOMM70	O94826	orf9b_sars2	SARS-CoV-2	P0DTD2	GMS	33060197
Cross	TOMM70	O94826	orf9b_sars2	SARS-CoV-2	P0DTD2	GMS	33990585
Cross	TOMM70	O94826	orf9b_sars2	SARS-CoV-2	P0DTD2	Confocal	32728199
Cross	TOMM70	O94826	orf9b_sars2	SARS-CoV-2	P0DTD2	Anti Tag CoIP	32728199
Cross	TOMM70	O94826	orf9b_sars2	SARS-CoV-2	P0DTD2	3D-EM	33060197
Cross	TOMM70	O94826	orf9b_sars2	SARS-CoV-2	P0DTD2	Pull Down	33990585
Cross	TOMM70	O94826	orf9b_sars2	SARS-CoV-2	P0DTD2	BLI	32728199
Intra	TOMM70	O94826	HSP90AA1	Homo sapiens	P07900	ITC	33990585
Cross	TOMM70	O94826	orf9b_sars	Human SARS coronavirus	P59636	Confocal	32728199
Cross	TOMM70	O94826	orf9b_sars	Human SARS coronavirus	P59636	BLI	32728199
Cross	TOMM70	O94826	orf9b_sars	Human SARS coronavirus	P59636	Confocal	33060197

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Myopathy, Centronuclear, 1

Autosomal Dominant Centronuclear Myopathy	CNM1
Centronuclear Myopathy 1	Ad-Cnm
Myopathy, Centronuclear, Autosomal Dominant	Myotubular Myopathy, Autosomal Dominant
Centronuclear Myopathy, Autosomal, Modifier Of	Autosomal Dominant Myotubular Myopathy
Dnm2-Related Centronuclear Myopathy	Centronuclear Myopathy Autosomal Dominant
Myopathies, Structural, Congenital	Myopathy, Centronuclear, Type 1

Microcephaly 7, Primary, Autosomal Recessive

MCPH7	Primary Autosomal Recessive Microcephaly 7
Microcephaly, Primary Autosomal Recessive, 7

Spastic Ataxia 5

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14887	TOMM70 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TOMM70	VGNC	VGNC:78618
Canis familiaris	TOMM70	VGNC	VGNC:49630
Felis catus	TOMM70	VGNC	VGNC:66446
Rattus norvegicus	TOMM70	RGD	RGD:1303049
Mus musculus	TOMM70	MGD	MGI:106295
Bos taurus	TOMM70	VGNC	VGNC:49582

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