2. Gene
  3. TOX4 - TOX high mobility group box family member 4 Gene

TOX4 - TOX high mobility group box family member 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LCP1; MIG7; C14orf92; KIAA0737

Gene ID: 9878 | Gene type: protein coding

About TOX4

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:21,477,195-21,499,170 (from NCBI)

This gene has 14 transcripts (splice variants), 278 orthologues and 20 paralogues.

Summary

Predicted to enable chromatin DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in chromatin. Part of PTW/PP1 Phosphatase complex. Colocalizes with chromosome, telomeric region. [provided by Alliance of Genome Resources, Apr 2022]

TOX4 Products(2)

mRNA Protein Name
NM_001303523.2 NP_001290452.1 TOX high mobility group box family member 4 isoform 2
NM_014828.4 NP_055643.1 TOX high mobility group box family member 4 isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16713569 GOA
Cellular Component GO Annotation Evidence Reference Source
part of PTW/PP1 phosphatase complex IDA
IDA: Inferred from direct assay
20516061 GOA
located in chromatin IDA
IDA: Inferred from direct assay
20516061 GOA
colocalizes with chromosome, telomeric region IDA
IDA: Inferred from direct assay
24270157 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TOX4 Protein Structure

HMG_box

HMG_box: HMG (high mobility group) box (200 - 268)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 598 a.a.
Protein Preferred Names Protein Names

TOX high mobility group box family member 4

epidermal Langerhans cell protein LCP1

Related Diseases

Diseases Alias
Breast Intraductal Papillomatosis

Breast Papillomatosis

Intraductal Papillomatosis Of The Breast
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14911 TOX4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TOX4 VGNC VGNC:99334
Rattus norvegicus TOX4 RGD RGD:708449
Canis familiaris TOX4 VGNC VGNC:55005
Felis catus TOX4 VGNC VGNC:66460
Bos taurus TOX4 VGNC VGNC:36230
Mus musculus TOX4 MGD MGI:1915389