TOX4 - TOX high mobility group box family member 4 Gene

Homo sapiens

Also known as LCP1; MIG7; C14orf92; KIAA0737

Gene ID: 9878 | Gene type: protein coding

About TOX4

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:21,477,195-21,499,170 (from NCBI)

This gene has 14 transcripts (splice variants), 278 orthologues and 20 paralogues.

Summary

Predicted to enable chromatin DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in chromatin. Part of PTW/PP1 Phosphatase complex. Colocalizes with chromosome, telomeric region. [provided by Alliance of Genome Resources, Apr 2022]

TOX4 Products(2)

mRNA	Protein	Name
NM_001303523.2	NP_001290452.1	TOX high mobility group box family member 4 isoform 2
NM_014828.4	NP_055643.1	TOX high mobility group box family member 4 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16713569	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of PTW/PP1 phosphatase complex	IDA IDA: Inferred from direct assay	20516061	GOA
located in chromatin	IDA IDA: Inferred from direct assay	20516061	GOA
colocalizes with chromosome, telomeric region	IDA IDA: Inferred from direct assay	24270157	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TOX4 Protein Structure

HMG_box

0
100
200
300
400
500
598 a.a.

Protein Preferred Names

Protein Names

TOX high mobility group box family member 4

epidermal Langerhans cell protein LCP1

TOX4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TOX4	O94842	MYL7	Homo sapiens	Q01449	Y2H Array	25416956
Intra	TOX4	O94842	MYL7	Homo sapiens	Q01449	Validated Y2H	25416956
Intra	TOX4	O94842	FNDC3B	Homo sapiens	Q53EP0-3	Validated Y2H	32296183
Intra	TOX4	O94842	FNDC3B	Homo sapiens	Q53EP0-3	Y2H Array	25416956
Intra	TOX4	O94842	FNDC3B	Homo sapiens	Q53EP0-3	Validated Y2H	25416956
Intra	TOX4	O94842	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	32296183
Intra	TOX4	O94842	QRICH1	Homo sapiens	Q2TAL8	Validated Y2H	32296183
Intra	TOX4	O94842	TBX6	Homo sapiens	O95947	Validated Y2H	32296183
Intra	TOX4	O94842	BANP	Homo sapiens	Q8N9N5	Y2H Array	25416956
Intra	TOX4	O94842	ZMYND19	Homo sapiens	Q96E35	Y2H Prey Pooling	25416956
Intra	TOX4	O94842	ZMYND19	Homo sapiens	Q96E35	Y2H Array	25416956
Intra	TOX4	O94842	ZMYND19	Homo sapiens	Q96E35	Validated Y2H	25416956
Intra	TOX4	O94842	ZMYND19	Homo sapiens	Q96E35	Validated Y2H	32296183
Intra	TOX4	O94842	GEMIN6	Homo sapiens	Q8WXD5	Y2H Array	25416956
Intra	TOX4	O94842	GEMIN6	Homo sapiens	Q8WXD5	Y2H Prey Pooling	25416956
Intra	TOX4	O94842	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	TOX4	O94842	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	TOX4	O94842	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	TOX4	O94842	ATXN1	Homo sapiens	P54253	Y2H	16713569

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Breast Intraductal Papillomatosis

Breast Papillomatosis

Intraductal Papillomatosis Of The Breast

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14911	TOX4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TOX4	VGNC	VGNC:99334
Rattus norvegicus	TOX4	RGD	RGD:708449
Canis familiaris	TOX4	VGNC	VGNC:55005
Felis catus	TOX4	VGNC	VGNC:66460
Bos taurus	TOX4	VGNC	VGNC:36230
Mus musculus	TOX4	MGD	MGI:1915389

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