2. Gene
  3. SMG7 - SMG7 nonsense mediated mRNA decay factor Gene

SMG7 - SMG7 nonsense mediated mRNA decay factor Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EST1C; SGA56M; C1orf16

Gene ID: 9887 | Gene type: protein coding

About SMG7

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:183,472,499-183,554,191 (from NCBI)

This gene has 16 transcripts (splice variants), 203 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 30.4), bone marrow (RPKM 12.9) and 25 other tissues.

Summary

This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]

SMG7 Products(25)

mRNA Protein Name
NM_001174061.2 NP_001167532.1 nonsense-mediated mRNA decay factor SMG7 isoform 5
NM_001331007.2 NP_001317936.1 nonsense-mediated mRNA decay factor SMG7 isoform 6
NM_001350219.2 NP_001337148.1 nonsense-mediated mRNA decay factor SMG7 isoform 7
NM_001350220.2 NP_001337149.1 nonsense-mediated mRNA decay factor SMG7 isoform 8
NM_001350221.2 NP_001337150.1 nonsense-mediated mRNA decay factor SMG7 isoform 6
NM_001375584.1 NP_001362513.1 nonsense-mediated mRNA decay factor SMG7 isoform 10
NM_001375585.1 NP_001362514.1 nonsense-mediated mRNA decay factor SMG7 isoform 11
NM_001394133.1 NP_001381062.1 nonsense-mediated mRNA decay factor SMG7 isoform 8
NM_001394134.1 NP_001381063.1 nonsense-mediated mRNA decay factor SMG7 isoform 12
NM_001394135.1 NP_001381064.1 nonsense-mediated mRNA decay factor SMG7 isoform 12
NM_001394136.1 NP_001381065.1 nonsense-mediated mRNA decay factor SMG7 isoform 12
NM_001394137.1 NP_001381066.1 nonsense-mediated mRNA decay factor SMG7 isoform 5
NM_001394138.1 NP_001381067.1 nonsense-mediated mRNA decay factor SMG7 isoform 7
NM_001394139.1 NP_001381068.1 nonsense-mediated mRNA decay factor SMG7 isoform 7
NM_001394140.1 NP_001381069.1 nonsense-mediated mRNA decay factor SMG7 isoform 13
NM_001394141.1 NP_001381070.1 nonsense-mediated mRNA decay factor SMG7 isoform 14
NM_001394142.1 NP_001381071.1 nonsense-mediated mRNA decay factor SMG7 isoform 15
NM_001394143.1 NP_001381072.1 nonsense-mediated mRNA decay factor SMG7 isoform 15
NM_001394144.1 NP_001381073.1 nonsense-mediated mRNA decay factor SMG7 isoform 16
NM_001394145.1 NP_001381074.1 nonsense-mediated mRNA decay factor SMG7 isoform 17
NM_001394146.1 NP_001381075.1 nonsense-mediated mRNA decay factor SMG7 isoform 17
NM_001394147.1 NP_001381076.1 nonsense-mediated mRNA decay factor SMG7 isoform 18
NM_173156.3 NP_775179.1 nonsense-mediated mRNA decay factor SMG7 isoform 1
NM_201568.3 NP_963862.1 nonsense-mediated mRNA decay factor SMG7 isoform 2
NM_201569.3 NP_963863.2 nonsense-mediated mRNA decay factor SMG7 isoform 4
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
14636577 GOA
enables protein phosphatase 2A binding IDA
IDA: Inferred from direct assay
14636577 GOA
enables telomeric DNA binding IDA
IDA: Inferred from direct assay
17916692 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
14636577 GOA
located in nucleus IDA
IDA: Inferred from direct assay
14636577 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMG7 Protein Structure

EST1

EST1: Telomerase activating protein Est1 (54 - 170)

EST1_DNA_bind

EST1_DNA_bind: Est1 DNA/RNA binding domain (171 - 430)

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  • 1137 a.a.
Protein Preferred Names Protein Names

nonsense-mediated mRNA decay factor SMG7

EST1 telomerase component homolog C

SMG7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SMG7 Q92540 SMG5 Homo sapiens Q9UPR3
Pull Down
23348841
Intra
SMG7 Q92540 UPF1 Homo sapiens Q92900
Pull Down
23348841
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pancreatic Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Pancreas

Adenosquamous Carcinoma Of The Pancreas
Murray Valley Encephalitis

Australian Encephalitis

Australian X Disease

Encephalitis Australia

Murray River Encephalitis

Australian Arboencephalitis

Australian X Disorder

Mve - [Murray Valley Encephalitis]
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-111374 NMDI14 Modulator 99.76% Unkown
HY-RS13433 SMG7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SMG7 VGNC VGNC:46557
Felis catus SMG7 VGNC VGNC:65489
Macaca mulatta SMG7 VGNC VGNC:77725
Rattus norvegicus SMG7 RGD RGD:1310761
Mus musculus SMG7 MGD MGI:2682334
Bos taurus SMG7 VGNC VGNC:35012