SMG5 - SMG5 nonsense mediated mRNA decay factor Gene

Homo sapiens

Also known as EST1B; SMG-5; LPTSRP1; LPTS-RP1

Gene ID: 23381 | Gene type: protein coding

About SMG5

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:156,249,224-156,291,516 (from NCBI)

This gene has 5 transcripts (splice variants), 209 orthologues and 1 paralogue. Ubiquitous expression in heart (RPKM 16.7), testis (RPKM 16.4) and 25 other tissues.

Summary

SMG5 is involved in nonsense-mediated mRNA decay (Ohnishi et al., 2003 [PubMed 14636577]).[supplied by OMIM, Mar 2008]

SMG5 Products(5)

mRNA	Protein	Name
NM_001323614.2	NP_001310543.1	nonsense-mediated mRNA decay factor SMG5 isoform 2
NM_001323615.2	NP_001310544.1	nonsense-mediated mRNA decay factor SMG5 isoform 3
NM_001323616.2	NP_001310545.1	nonsense-mediated mRNA decay factor SMG5 isoform 4
NM_001323617.2	NP_001310546.1	nonsense-mediated mRNA decay factor SMG5 isoform 4
NM_015327.3	NP_056142.2	nonsense-mediated mRNA decay factor SMG5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	16809764	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12699629	GOA
enables protein phosphatase 2A binding	IDA IDA: Inferred from direct assay	14636577	GOA
enables telomerase RNA binding	IPI IPI: Inferred from physical interaction	15857955	GOA
enables telomeric DNA binding	IDA IDA: Inferred from direct assay	17916692	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	16809764	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of dephosphorylation	IMP IMP: Inferred from mutant phenotype	14636577	GOA
involved in regulation of telomere maintenance	IMP IMP: Inferred from mutant phenotype	16809764	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	14636577	GOA
located in nucleus	IDA IDA: Inferred from direct assay	14636577	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMG5 Protein Structure

EST1

EST1_DNA_bind

PIN_4

0
200
400
600
800
1016 a.a.

Protein Preferred Names

Protein Names

nonsense-mediated mRNA decay factor SMG5

EST1 telomerase component homolog B

SMG5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SMG5	Q9UPR3	SMG7	Homo sapiens	Q92540	Pull Down	23348841

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pancreatic Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Pancreas

Adenosquamous Carcinoma Of The Pancreas

Metaphyseal Chondrodysplasia, Schmid Type

MCDS	Schmid Metaphyseal Chondrodysplasia
Metaphyseal Chondrodysplasia Schmid Type	Spondylometaphyseal Dysplasia, Japanese Type
Japanese Type Spondylometaphyseal Dysplasia	Schmid Type Metaphyseal Dysplasia
Metaphyseal Chondrodysplasia Type Schmid	Schmid Type Metaphyseal Chondrodysplasia
SMCD	Chondrodysplasia, Metaphyseal, Schmid Type
Corneal Dystrophy, Subepithelial Mucinous

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13431	SMG5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SMG5	VGNC	VGNC:65487
Macaca mulatta	SMG5	VGNC	VGNC:77768
Mus musculus	SMG5	MGD	MGI:2447364
Bos taurus	SMG5	VGNC	VGNC:55683
Canis familiaris	SMG5	VGNC	VGNC:46555
Rattus norvegicus	SMG5	RGD	RGD:1584731

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