1. Gene
  2. ATP2C2 - ATPase secretory pathway Ca2+ transporting 2 Gene

ATP2C2 - ATPase secretory pathway Ca2+ transporting 2 Gene

Homo sapiens

Also known as SPCA2

Gene ID: 9914 | Gene type: protein coding

About ATP2C2

Cytogenetic location: 16q24.1 Genomic coordinates (GRCh38): 16:84,368,538-84,464,187 (from NCBI)

This gene has 15 transcripts (splice variants), 312 orthologues and 21 paralogues. Biased expression in colon (RPKM 16.5), skin (RPKM 9.9) and 12 other tissues.

Summary

Enables P-type calcium transporter activity and P-type manganese transporter activity. Predicted to be involved in calcium ion transmembrane transport; cellular calcium ion homeostasis; and manganese ion transport. Predicted to act upstream of or within mammary gland epithelium development; positive regulation of calcium ion import; and protein localization to plasma membrane. Predicted to be located in trans-Golgi network membrane. Predicted to be active in Golgi membrane; endoplasmic reticulum; and plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

ATP2C2 Products(3)

mRNA Protein Name
NM_001286527.3 NP_001273456.2 calcium-transporting ATPase type 2C member 2 isoform 1
NM_001291454.2 NP_001278383.1 calcium-transporting ATPase type 2C member 2 isoform 3
NM_014861.4 NP_055676.3 calcium-transporting ATPase type 2C member 2 isoform 2
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables P-type calcium transporter activity IDA
IDA: Inferred from direct assay
15677451 GOA
enables P-type manganese transporter activity IDA
IDA: Inferred from direct assay
15831496 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20887894 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP2C2 Protein Structure

Cation_ATPase_N

Cation_ATPase_N: Cation transporter/ATPase, N-terminus (62 - 125)

E1-E2_ATPase

E1-E2_ATPase: E1-E2 ATPase (136 - 369)

Hydrolase

Hydrolase: haloacid dehalogenase-like hydrolase (374 - 686)

Cation_ATPase_C

Cation_ATPase_C: Cation transporting ATPase, C-terminus (756 - 928)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 946 a.a.
Protein Preferred Names Protein Names

calcium-transporting ATPase type 2C member 2

ATPase 2C2

ATP2C2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ATP2C2 O75185 ORAI1 Homo sapiens Q96D31
Anti Tag CoIP
20887894
Intra
ATP2C2 O75185 ORAI1 Homo sapiens Q96D31
Anti Bait CoIP
20887894
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Dyslexia
Benign Chronic Pemphigus

Hailey-Hailey Disease

Pemphigus, Benign Familial

Familial Benign Pemphigus

Benign Familial Pemphigus

Familial Benign Chronic Pemphigus

BCPM

HHD

Benign Chronic Familial Pemphigus Of Hailey-Hailey

Pemphigus, Chronic, Benign

Speech And Communication Disorders

Language Disorder

Communication Disorder

Language Disorders

Communication Disorders

Speech Language Disorder

Speech-Language Disorder

Communication Impairment

Speech And Language Disorder

Reading Disorder

Specific Reading Disorder

Reading

Dyslexia

Developmental Reading Disorder

Triple-Receptor Negative Breast Cancer
Expressive Language Disorder

Developmental Expressive Language Disorder

Specific Language Impairment

Language Impairment, Specific

Developmental Coordination Disorder

Motor Skills Disorders

Mixed Receptive-Expressive Language Disorder
Learning Disability

Learning Disabilities

Learning Disorders

Academic Skill Disorder

Learning Disorder

Speech Disorder

Speech Disorders

Stuttering

Stammering

Familial Persistent Stuttering

Stuttering, Familial Persistent 1

Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity

Benign Epilepsy With Centrotemporal Spikes

Rolandic Epilepsy

Benign Rolandic Epilepsy

Epilepsy, Rolandic

Bcects

Benign Childhood Epilepsy With Centrotemporal Spike

Sylvan Seizures

Becrs

Bects

Bre

Benign Epilepsy Of Childhood With Centrotemporal Spikes

Benign Familial Epilepsy Of Childhood With Rolandic Spikes

Centrotemporal Epilepsy

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ATP2C2 RGD RGD:620647
Macaca mulatta ATP2C2 VGNC VGNC:70149
Bos taurus ATP2C2 VGNC VGNC:26297
Canis familiaris ATP2C2 VGNC VGNC:38261
Mus musculus ATP2C2 MGD MGI:1916297
Felis catus ATP2C2 VGNC VGNC:60020