GFPT2 - glutamine-fructose-6-phosphate transaminase 2 Gene

Homo sapiens

Also known as GFAT; GFAT2; GFAT 2

Gene ID: 9945 | Gene type: protein coding

About GFPT2

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:180,300,698-180,353,336 (from NCBI)

This gene has 8 transcripts (splice variants), 215 orthologues and 1 paralogue. Broad expression in appendix (RPKM 10.6), gall bladder (RPKM 9.6) and 23 other tissues.

Summary

Predicted to enable glutamine-fructose-6-phosphate transaminase (isomerizing) activity. Predicted to be involved in UDP-N-acetylglucosamine metabolic process; fructose 6-phosphate metabolic process; and protein N-linked glycosylation. Predicted to act upstream of or within cellular response to Leukemia Inhibitory Factor. Predicted to be located in cytosol. Implicated in type 2 diabetes mellitus. [provided by Alliance of Genome Resources, Apr 2022]

GFPT2 Products(1)

mRNA	Protein	Name
NM_005110.4	NP_005101.1	glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity	IDA IDA: Inferred from direct assay	35229715	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in UDP-N-acetylglucosamine biosynthetic process	IDA IDA: Inferred from direct assay	35229715	GOA
involved in fructose 6-phosphate metabolic process	IDA IDA: Inferred from direct assay	35229715	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GFPT2 Protein Structure

GATase_2

SIS

0
200
400
600
682 a.a.

Protein Preferred Names

Protein Names

glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

D-fructose-6-phosphate amidotransferase 2

GFPT2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GFPT2	O94808	GFPT1	Homo sapiens	Q06210	Anti Tag CoIP	33961781
Intra	GFPT2	O94808	POT1	Homo sapiens	Q9NUX5	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

GFPT2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83169	GFPT2 Antibody (YA2914)	WB, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Alzheimer Disease 19

AD19	Alzheimer'S Disease 19
Alzheimer Disease 19, Late-Onset	Alzheimer Disease 19 Late Onset
Late-Onset Alzheimer Disease	Alzheimer Disease, Late Onset, Susceptibility To, Type 19
Alzheimer Disease, Late Onset

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Diabetes Mellitus

Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05385	GFPT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GFPT2	RGD	RGD:1303097
Felis catus	GFPT2	VGNC	VGNC:62528
Bos taurus	GFPT2	VGNC	VGNC:29331
Canis familiaris	GFPT2	VGNC	VGNC:41188
Mus musculus	GFPT2	MGD	MGI:1338883
Macaca mulatta	GFPT2	VGNC	VGNC:72916

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