NUP153 - nucleoporin 153 Gene

Homo sapiens

Also known as N153; HNUP153

Gene ID: 9972 | Gene type: protein coding

About NUP153

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:17,615,037-17,706,925 (from NCBI)

This gene has 3 transcripts (splice variants), 200 orthologues and 6 paralogues. Ubiquitous expression in testis (RPKM 19.5), bone marrow (RPKM 18.1) and 25 other tissues.

Summary

Nuclear pore complexes regulate the transport of macromolecules between the nucleus and cytoplasm. They are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are glycoproteins found in nuclear pores and contain characteristic pentapeptide XFXFG repeats as well as O-linked N-acetylglucosamine residues oriented towards the cytoplasm. The protein encoded by this gene has three distinct domains: a N-terminal region containing a pore targeting and an RNA-binding domain domain, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

NUP153 Products(3)

mRNA	Protein	Name
NM_001278209.2	NP_001265138.1	nuclear pore complex protein Nup153 isoform 1
NM_001278210.2	NP_001265139.1	nuclear pore complex protein Nup153 isoform 3
NM_005124.4	NP_005115.2	nuclear pore complex protein Nup153 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	23238392	GOA
enables molecular condensate scaffold activity	IDA IDA: Inferred from direct assay	21961597	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11777942	GOA
enables protein-membrane adaptor activity	IMP IMP: Inferred from mutant phenotype	12802065	GOA
enables structural constituent of nuclear pore	IDA IDA: Inferred from direct assay	22253824	GOA
enables structural constituent of nuclear pore	IMP IMP: Inferred from mutant phenotype	15229283	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in amyloid fibril formation	IPI IPI: Inferred from physical interaction	23238392	GOA
involved in negative regulation of RNA export from nucleus	IDA IDA: Inferred from direct assay	22253824	GOA
involved in nuclear pore complex assembly	IMP IMP: Inferred from mutant phenotype	12802065	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IMP IMP: Inferred from mutant phenotype	26051542	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	24315095	GOA
located in nuclear inclusion body	IDA IDA: Inferred from direct assay	11839768	GOA
located in nuclear membrane	IDA IDA: Inferred from direct assay	11839768	GOA
located in nuclear periphery	IDA IDA: Inferred from direct assay	11839768	GOA
part of nuclear pore	IDA IDA: Inferred from direct assay	12802065	GOA
part of nuclear pore nuclear basket	IDA IDA: Inferred from direct assay	11839768	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUP153 Protein Structure

Nup153

zf-RanBP

Nup_retrotrp_bd

0
300
600
900
1200
1475 a.a.

Protein Preferred Names

Protein Names

nuclear pore complex protein Nup153

153 kDa nucleoporin

NUP153 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NUP153	P49790	KPNB1	Homo sapiens	Q14974	Anti Bait CoIP	21858095
Intra	NUP153	P49790	KPNB1	Homo sapiens	Q14974	Anti Tag CoIP	35271311
Intra	NUP153	P49790	KPNB1	Homo sapiens	Q14974	Anti Tag CoIP	26496610
Intra	NUP153	P49790	RAN	Homo sapiens	P62826	Anti Tag CoIP	26496610
Intra	NUP153	P49790	KPNA2	Homo sapiens	P52292	Anti Tag CoIP	26496610
Intra	NUP153	P49790	NXF1	Homo sapiens	Q9UBU9	Anti Tag CoIP	26496610
Intra	NUP153	P49790	NXF1	Homo sapiens	Q9UBU9	Pull Down	10668806

Cross: Cross-species interaction Intra: Intraspecies interaction

NUP153 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81926	NUP153 Antibody (YA1671)	WB, ICC/IF, FC	Human

Related Diseases

Diseases

Alias

Carnitine-Acylcarnitine Translocase Deficiency

Cact Deficiency	Carnitine Acylcarnitine Translocase Deficiency
CACTD	Carnitine-Acylcarnitine Carrier Deficiency

Achalasia-Addisonianism-Alacrima Syndrome

Allgrove Syndrome	Triple-A Syndrome
Achalasia-Addisonianism-Alacrimia Syndrome	Alacrima-Achalasia-Adrenal Insufficiency Neurologic Disorder
Triple A Syndrome	Aaa Syndrome
AAAS	Glucocorticoid Deficiency With Achalasia
Glucocorticoid Deficiency And Achalasia	Addisonian-Achalasia Syndrome
Hypoadrenalism With Achalasia	Alacrima-Achalasia-Addisonianism
Aaa	Acth-Resistant Adrenal Insufficiency, Achalasia And Alacrima
Achalasia Addisonianism Alacrimia Syndrome	Achalasia Alacrima Syndrome
Addisonian Achalasia Syndrome	Achalasia-Addisonian Syndrome
Achalasia-Alacrima Syndrome	2a Syndrome
3a Syndrome	4a Syndrome
Adrenal Insufficiency-Achalasia-Alacrima Syndrome	Double A Syndrome
Quaternary A Syndrome	Acth-Resistant Adrenal Insufficiency With Achalasia And Alacrima
Allgrove'S Syndrome	Adrenal Gland Hypofunction
Adrenal Cortical Hypofunction

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120072	PF-3450074	Inhibitor	98.44%	Unkown
HY-RS09685	NUP153 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NUP153	MGD	MGI:2385621
Rattus norvegicus	NUP153	RGD	RGD:3216
Macaca mulatta	NUP153	VGNC	VGNC:75559
Canis familiaris	NUP153	VGNC	VGNC:54978
Bos taurus	NUP153	VGNC	VGNC:50235
Felis catus	NUP153	VGNC	VGNC:68598

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