FGFBP1 - fibroblast growth factor binding protein 1 Gene

Homo sapiens

Also known as FGFBP; HBP17; FGF-BP; FGF-BP1; FGFBP-1

Gene ID: 9982 | Gene type: protein coding

About FGFBP1

Cytogenetic location: 4p15.32 Genomic coordinates (GRCh38): 4:15,935,577-15,938,740 (from NCBI)

This gene has 1 transcript (splice variant), 220 orthologues and 2 paralogues. Biased expression in esophagus (RPKM 137.5), skin (RPKM 14.8) and 1 other tissue.

Summary

This gene encodes a secreted Fibroblast Growth Factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of Cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]

FGFBP1 Products(1)

mRNA	Protein	Name
NM_005130.5	NP_005121.1	fibroblast growth factor-binding protein 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16257968	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IDA IDA: Inferred from direct assay	27121396	GOA
involved in positive regulation of cell migration involved in sprouting angiogenesis	IDA IDA: Inferred from direct assay	27121396	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FGFBP1 Protein Structure

FGF-BP1

0
100
200
234 a.a.

Protein Preferred Names

Protein Names

fibroblast growth factor-binding protein 1

17 kDa HBGF-binding protein

FGFBP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FGFBP1	Q14512	FGF2	Homo sapiens	P09038	Competition Binding	16257968
Intra	FGFBP1	Q14512	FGF2	Homo sapiens	P09038	SPR	16257968
Intra	FGFBP1	Q14512	FGF2	Homo sapiens	P09038	T7 Phage	16257968

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Colorectal Adenocarcinoma

Adenocarcinoma Of Large Intestine

Spinal Muscular Atrophy, Type Ii

SMA2	Sma Ii
Muscular Atrophy, Spinal, Intermediate Type	Muscular Atrophy, Spinal, Infantile Chronic Form
Intermediate Spinal Muscular Atrophy	Spinal Muscular Atrophy Type Ii
Spinal Muscular Atrophy-2	Spinal Muscular Atrophy 2
Spinal Muscular Atrophy Type 2	Dubowitz Disease
Proximal Spinal Muscular Atrophy Type 2	Sma Type 2
Sma Type Ii	Sma-Ii
Spinal Muscular Atrophy Infantile Chronic Form	Spinal Muscular Atrophy Intermediate Type
Spinal Muscular Atrophies Of Childhood	Atrophy, Muscular, Spinal, Type Ii
Muscular Atrophy, Spinal, Type Ii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04908	FGFBP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FGFBP1	MGD	MGI:1096350
Macaca mulatta	FGFBP1	VGNC	VGNC:72536
Felis catus	FGFBP1	VGNC	VGNC:82351
Rattus norvegicus	FGFBP1	RGD	RGD:621211
Canis familiaris	FGFBP1	VGNC	VGNC:49742

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