Prmt6 - protein arginine N-methyltransferase 6 Gene

Mus musculus

Also known as Hrmt1l6

Gene ID: 99890 | Gene type: protein coding

About Prmt6

Chromosome 3: 110,153,425-110,158,314 reverse strand.GRCm39:CM000996.3

This gene has 3 transcripts (splice variants), 166 orthologues, 7 paralogues and is associated with 11 phenotypes. Ubiquitous expression in ovary adult (RPKM 8.9), adrenal adult (RPKM 6.9) and 28 other tissues.

Summary

Enables chromatin binding activity and histone-arginine N-methyltransferase activity. Involved in peptidyl-arginine N-methylation. Acts upstream of or within several processes, including cellular senescence; histone H3-R2 methylation; and negative regulation of nitrogen compound metabolic process. Predicted to be located in nucleolus and nucleoplasm. Is expressed in central nervous system and sensory organ. Orthologous to human PRMT6 (protein arginine methyltransferase 6). [provided by Alliance of Genome Resources, Apr 2022]

Prmt6 Products(1)

mRNA	Protein	Name
NM_178891.5	NP_849222.3	protein arginine N-methyltransferase 6

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	22904064	MGI
enables histone H3R2 methyltransferase activity	IMP IMP: Inferred from mutant phenotype	22904064	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	26070566	MGI
enables protein-arginine N-methyltransferase activity	IDA IDA: Inferred from direct assay	18495660	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular senescence	IMP IMP: Inferred from mutant phenotype	22904064	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22904064	MGI
involved in negative regulation of ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	26070566	MGI
acts upstream of or within regulation of signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	22904064	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prmt6 Protein Structure

AdoMet_MTases

0
100
200
300
378 a.a.

Protein Preferred Names

Protein Names

protein arginine N-methyltransferase 6

HMT1 hnRNP methyltransferase-like 6

histone-arginine N-methyltransferase PRMT6

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-128717	GSK3368715	Inhibitor	/	Phase 1
HY-128717B	GSK3368715 trihydrochloride	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19615	MS023	Inhibitor	99.73%	Unkown
HY-114965	TP-064	Inhibitor	99.61%	Unkown
HY-12970A	EPZ020411 hydrochloride	Inhibitor	98.15%	Unkown
HY-12970	EPZ020411	Inhibitor	98.06%	Unkown
HY-19615B	MS023 dihydrochloride	Inhibitor	99.78%	Unkown
HY-133740	MS117	Inhibitor	≥98.0%	Unkown
HY-100360	MS049	Inhibitor	≥98.0%	Unkown
HY-100565A	SGC2085 hydrochloride	Inhibitor	/	Unkown
HY-161334	CARM1-IN-4	Inhibitor	/	Unkown
HY-146810	PRMT4-IN-1	Inhibitor	/	Unkown
HY-117927	EPZ0025654	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prmt6	NCBI	NCBI:55170

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