2. Gene
  3. Prmt6 - protein arginine N-methyltransferase 6 Gene

Prmt6 - protein arginine N-methyltransferase 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Hrmt1l6

Gene ID: 99890 | Gene type: protein coding

About Prmt6

Chromosome 3: 110,153,425-110,158,314 reverse strand.GRCm39:CM000996.3

This gene has 3 transcripts (splice variants), 166 orthologues, 7 paralogues and is associated with 11 phenotypes. Ubiquitous expression in ovary adult (RPKM 8.9), adrenal adult (RPKM 6.9) and 28 other tissues.

Summary

Enables chromatin binding activity and histone-arginine N-methyltransferase activity. Involved in peptidyl-arginine N-methylation. Acts upstream of or within several processes, including cellular senescence; histone H3-R2 methylation; and negative regulation of nitrogen compound metabolic process. Predicted to be located in nucleolus and nucleoplasm. Is expressed in central nervous system and sensory organ. Orthologous to human PRMT6 (protein arginine methyltransferase 6). [provided by Alliance of Genome Resources, Apr 2022]

Prmt6 Products(1)

mRNA Protein Name
NM_178891.5 NP_849222.3 protein arginine N-methyltransferase 6

Prmt6 Protein Structure

AdoMet_MTases

AdoMet_MTases: cd02440 (87 - 187)

  • 0
  • 100
  • 200
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  • 378 a.a.
Protein Preferred Names Protein Names

protein arginine N-methyltransferase 6

HMT1 hnRNP methyltransferase-like 6

histone-arginine N-methyltransferase PRMT6

Related Agents

Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19615 MS023 Inhibitor 99.73% Unkown
HY-114965 TP-064 Inhibitor 99.61% Unkown
HY-12970A EPZ020411 hydrochloride Inhibitor 98.15% Unkown
HY-12970 EPZ020411 Inhibitor 98.06% Unkown
HY-19615B MS023 dihydrochloride Inhibitor 99.78% Unkown
HY-133740 MS117 Inhibitor ≥98.0% Unkown
HY-100360 MS049 Inhibitor ≥98.0% Unkown
HY-128717B GSK3368715 trihydrochloride Inhibitor / Unkown
HY-146810 PRMT4-IN-1 Inhibitor / Unkown
HY-100565A SGC2085 hydrochloride Inhibitor / Unkown
HY-161334 CARM1-IN-4 Inhibitor / Unkown
HY-117927 EPZ0025654 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prmt6 NCBI NCBI:55170