Kdm1a - lysine (K)-specific demethylase 1A Gene

Mus musculus

Also known as Aof2; Kdm1; Lsd1; mKIAA0601; D4Ertd478e; 1810043O07Rik

Gene ID: 99982 | Gene type: protein coding

About Kdm1a

Chromosome 4: 136,277,851-136,330,034 reverse strand.GRCm39:CM000997.3

This gene has 9 transcripts (splice variants), 215 orthologues, 9 paralogues and is associated with 39 phenotypes. Ubiquitous expression in CNS E14 (RPKM 42.5), whole brain E14.5 (RPKM 4.5) and 28 other tissues.

Summary

Enables several functions, including DNA-binding transcription factor binding activity; histone H3-di/monomethyl-lysine-4 FAD-dependent demethylase activity; and promoter-specific chromatin binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of cell population proliferation; and regulation of myeloid cell differentiation. Acts upstream of or within histone H3-K4 demethylation; nervous system development; and positive regulation of transcription by RNA polymerase II. Located in chromatin and nucleus. Is expressed in several structures, including brain; inner cell mass; reproductive system; retina; and urinary system. Orthologous to human KDM1A (lysine demethylase 1A). [provided by Alliance of Genome Resources, Apr 2022]

Kdm1a Products(3)

mRNA	Protein	Name
NM_001347221.1	NP_001334150.1	lysine-specific histone demethylase 1A isoform 1
NM_001356567.1	NP_001343496.1	lysine-specific histone demethylase 1A isoform 3
NM_133872.2	NP_598633.2	lysine-specific histone demethylase 1A isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	20833138	MGI
enables FAD-dependent H3K4me/H3K4me3 demethylase activity	IDA IDA: Inferred from direct assay	24843136	MGI
enables MRF binding	IPI IPI: Inferred from physical interaction	20833138	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	28053041	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	20123967	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	17392792	MGI
enables enzyme binding	IPI IPI: Inferred from physical interaction	17277772	MGI
enables histone H3K4 demethylase activity	IMP IMP: Inferred from mutant phenotype	24217620	MGI
enables histone H3K9me2/H3K9me3 demethylase activity	IMP IMP: Inferred from mutant phenotype	20833138	MGI
enables lncRNA binding	IDA IDA: Inferred from direct assay	27618650	MGI
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	19497860	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17296600	MGI
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	20123967	MGI
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	17707228	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA repair-dependent chromatin remodeling	IDA IDA: Inferred from direct assay	24217620	MGI
acts upstream of or within cell differentiation	IMP IMP: Inferred from mutant phenotype	17392792	MGI
involved in granulocyte differentiation	IMP IMP: Inferred from mutant phenotype	17707228	MGI
involved in muscle cell development	IMP IMP: Inferred from mutant phenotype	20833138	MGI
acts upstream of or within negative regulation of neurogenesis	IDA IDA: Inferred from direct assay	25018020	MGI
acts upstream of or within negative regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	25018020	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19497860	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17392792	MGI
acts upstream of or within neuron projection extension	IGI IGI: Inferred from genetic interaction	25018020	MGI
acts upstream of or within neuron projection extension	IMP IMP: Inferred from mutant phenotype	25018020	MGI
acts upstream of or within pituitary gland development	IMP IMP: Inferred from mutant phenotype	17392792	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	27566776	MGI
involved in positive regulation of erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	17707228	MGI
involved in positive regulation of megakaryocyte differentiation	IMP IMP: Inferred from mutant phenotype	17707228	MGI
involved in positive regulation of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	20123967	MGI
involved in positive regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	20123967	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17392792	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20123967	MGI
acts upstream of or within regulation of neurogenesis	IGI IGI: Inferred from genetic interaction	25018020	MGI
involved in regulation of primitive erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	17707228	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17392792	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	20833138	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19497860	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Kdm1a Protein Structure

PHA03378

PLN02328

0
200
400
600
800
873 a.a.

Protein Preferred Names

Protein Names

lysine-specific histone demethylase 1A

BRAF35-HDAC complex protein BHC110	amine oxidase (flavin containing) domain 2
flavin-containing amine oxidase domain-containing protein 2	lysine (K)-specific demethylase 1
lysine-specific histone demethylase 1

Kdm1a Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Kdm1a	Q6ZQ88	Rcor1	Mus musculus	Q8CFE3	Anti Bait CoIP	17392792
Intra	Kdm1a	Q6ZQ88	Cebpa	Mus musculus	P53566	Anti Bait CoIP	26974661
Intra	Kdm1a	Q6ZQ88	Hdac1	Mus musculus	O09106	Anti Bait CoIP	26974661
Intra	Kdm1a	Q6ZQ88	Hdac1	Mus musculus	O09106	Anti Bait CoIP	20404188
Intra	Kdm1a	Q6ZQ88	Hdac1	Mus musculus	O09106	Anti Bait CoIP	22297846
Intra	Kdm1a	Q6ZQ88	Hdac2	Mus musculus	P70288	Anti Bait CoIP	20404188
Intra	Kdm1a	Q6ZQ88	Rnf2	Mus musculus	Q9CQJ4	Anti Bait CoIP	17296600

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-18632	GSK2879552	Inhibitor	99.90%	Phase 2
HY-103713	Seclidemstat	Inhibitor	99.77%	Phase 2
HY-18632A	GSK2879552 dihydrochloride	Inhibitor	99.19%	Phase 2
HY-109117	Iadademstat	Inhibitor	99.61%	Phase 2
HY-12782T	Iadademstat dihydrochloride	Inhibitor	99.98%	Phase 1
HY-138830	TAK-418	Inhibitor	99.10%	Phase 1

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103713A	Seclidemstat mesylate	Inhibitor	99.60%	Unkown
HY-19612B	DDP-38003 trihydrochloride	Inhibitor	/	Unkown
HY-19612A	DDP-38003 dihydrochloride	Inhibitor	98.22%	Unkown
HY-112304	NCD38 TFA	Inhibitor	/	Unkown
HY-112304A	(1R,2S)-NCD38 TFA	Inhibitor	/	Unkown
HY-143238	FY-56	Inhibitor	/	Unkown
HY-RS07205	KDM1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07206	Kdm1a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07207	Kdm1a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kdm1a	NCBI	NCBI:23028

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