2. Gene
  3. KDM1A - lysine demethylase 1A Gene

KDM1A - lysine demethylase 1A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AOF2; CPRF; KDM1; LSD1; BHC110

Gene ID: 23028 | Gene type: protein coding

About KDM1A

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:23,019,468-23,083,689 (from NCBI)

This gene has 36 transcripts (splice variants), 215 orthologues, 7 paralogues and is associated with 4 phenotypes. Broad expression in testis (RPKM 45.8), endometrium (RPKM 15.8) and 25 other tissues.

Summary

This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a Histone Demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

KDM1A Products(11)

mRNA Protein Name
XM_017000717.2 XP_016856206.1 lysine-specific histone demethylase 1A isoform X6
NM_015013.4 NP_055828.2 lysine-specific histone demethylase 1A isoform b
XM_005245786.3 XP_005245843.1 lysine-specific histone demethylase 1A isoform X2
NM_001410762.1 NP_001397691.1 lysine-specific histone demethylase 1A isoform d
NM_001410763.1 NP_001397692.1 lysine-specific histone demethylase 1A isoform e
XM_047449677.1 XP_047305633.1 lysine-specific histone demethylase 1A isoform X5
XM_017000716.2 XP_016856205.1 lysine-specific histone demethylase 1A isoform X4
NM_001363654.2 NP_001350583.1 lysine-specific histone demethylase 1A isoform c
XM_006710474.4 XP_006710537.1 lysine-specific histone demethylase 1A isoform X1
NM_001009999.3 NP_001009999.1 lysine-specific histone demethylase 1A isoform a
XM_006710473.4 XP_006710536.1 lysine-specific histone demethylase 1A isoform X3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription factor binding IDA
IDA: Inferred from direct assay
20833138 GOA
enables FAD-dependent H3K4me/H3K4me3 demethylase activity IDA
IDA: Inferred from direct assay
20228790 GOA
enables MRF binding IDA
IDA: Inferred from direct assay
20833138 GOA
enables chromatin binding IDA
IDA: Inferred from direct assay
16079795 GOA
enables demethylase activity IMP
IMP: Inferred from mutant phenotype
17805299 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
17277772 GOA
enables flavin adenine dinucleotide binding IDA
IDA: Inferred from direct assay
15620353 GOA
enables histone H3K4 demethylase activity IDA
IDA: Inferred from direct assay
15620353 GOA
enables histone H3K9 demethylase activity IDA
IDA: Inferred from direct assay
16079795 GOA
enables histone demethylase activity EXP
EXP: Inferred from Experiment
16079795 GOA
enables histone demethylase activity IDA
IDA: Inferred from direct assay
19497860 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
23455924 GOA
enables nuclear androgen receptor binding IDA
IDA: Inferred from direct assay
16079795 GOA
enables nuclear receptor coactivator activity IMP
IMP: Inferred from mutant phenotype
16079795 GOA
enables oxidoreductase activity IDA
IDA: Inferred from direct assay
15620353 GOA
enables p53 binding IPI
IPI: Inferred from physical interaction
17805299 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16169070 GOA
NOT enables telomeric DNA binding IDA
IDA: Inferred from direct assay
24529708 GOA
enables telomeric repeat-containing RNA binding IDA
IDA: Inferred from direct assay
24529708 GOA
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
20833138 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within DNA repair-dependent chromatin remodeling IDA
IDA: Inferred from direct assay
24217620 GOA
acts upstream of or within cellular response to UV IDA
IDA: Inferred from direct assay
24217620 GOA
acts upstream of or within cellular response to gamma radiation IMP
IMP: Inferred from mutant phenotype
24217620 GOA
involved in negative regulation of DNA damage response, signal transduction by p53 class mediator IMP
IMP: Inferred from mutant phenotype
17805299 GOA
involved in negative regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
19497860 GOA
involved in negative regulation of DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
17805299 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
19497860 GOA
involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
IMP: Inferred from mutant phenotype
17805299 GOA
involved in negative regulation of protein binding IMP
IMP: Inferred from mutant phenotype
17805299 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17805299 GOA
involved in positive regulation of epithelial to mesenchymal transition IDA
IDA: Inferred from direct assay
27292636 GOA
involved in positive regulation of neuroblast proliferation IMP
IMP: Inferred from mutant phenotype
23400681 GOA
acts upstream of or within positive regulation of protein ubiquitination IMP
IMP: Inferred from mutant phenotype
24217620 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20833138 GOA
involved in protein demethylation IMP
IMP: Inferred from mutant phenotype
17805299 GOA
involved in regulation of DNA methylation-dependent heterochromatin formation IDA
IDA: Inferred from direct assay
33980486 GOA
acts upstream of or within regulation of double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
24217620 GOA
acts upstream of or within regulation of protein localization IMP
IMP: Inferred from mutant phenotype
24217620 GOA
involved in regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16079795 GOA
Cellular Component GO Annotation Evidence Reference Source
part of DNA repair complex IDA
IDA: Inferred from direct assay
24217620 GOA
is active in chromatin IDA
IDA: Inferred from direct assay
27292636 GOA
located in chromatin IDA
IDA: Inferred from direct assay
17277772 GOA
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
24529708 GOA
is active in nucleus IDA
IDA: Inferred from direct assay
33980486 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16079795 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
24217620 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KDM1A Protein Structure

SWIRM

SWIRM: SWIRM domain (175 - 264)

Amino_oxidase

Amino_oxidase: Flavin containing amine oxidoreductase (288 - 826)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 852 a.a.
Protein Preferred Names Protein Names

lysine-specific histone demethylase 1A

BRAF35-HDAC complex protein BHC110

FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit

[histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A

amine oxidase (flavin containing) domain 2

flavin-containing amine oxidase domain-containing protein 2

lysine (K)-specific demethylase 1A

lysine-specific histone demethylase 1

KDM1A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
KDM1A O60341 NF2 Homo sapiens P35240
Y2H
23455924
Intra
KDM1A O60341 NF2 Homo sapiens P35240
Validated Y2H
32814053
Intra
KDM1A O60341 NF2 Homo sapiens P35240
Y2H Array
32814053
Intra
KDM1A O60341 NF2 Homo sapiens P35240
Y2H Pooling
32814053
Intra
KDM1A O60341 KRT40 Homo sapiens Q6A162
Validated Y2H
32296183
Intra
KDM1A O60341 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 KRT40 Homo sapiens Q6A162
Y2H Array
32296183
Intra
KDM1A O60341 NECAB2 Homo sapiens Q7Z6G3-2
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 NECAB2 Homo sapiens Q7Z6G3-2
Validated Y2H
32296183
Intra
KDM1A O60341 NECAB2 Homo sapiens Q7Z6G3-2
Y2H Array
32296183
Intra
KDM1A O60341 PBX4 Homo sapiens Q9BYU1
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 PBX4 Homo sapiens Q9BYU1
Validated Y2H
32296183
Intra
KDM1A O60341 PBX4 Homo sapiens Q9BYU1
Y2H Array
32296183
Intra
KDM1A O60341 SNAI1 Homo sapiens O95863
Pull Down
20562920
Intra
KDM1A O60341 SNAI1 Homo sapiens O95863
Anti Bait CoIP
20389281
Intra
KDM1A O60341 SNAI1 Homo sapiens O95863
Anti Tag CoIP
20389281
Intra
KDM1A O60341 SNAI1 Homo sapiens O95863
Pull Down
20389281
Intra
KDM1A O60341 SNAI1 Homo sapiens O95863
Anti Bait CoIP
20562920
Intra
KDM1A O60341 AKAP9 Homo sapiens Q99996
Anti Tag CoIP
23455924
Intra
KDM1A O60341 KRT33B Homo sapiens Q14525
Y2H Array
32296183
Intra
KDM1A O60341 KRT33B Homo sapiens Q14525
Y2H
23455924
Intra
KDM1A O60341 KRT33B Homo sapiens Q14525
Validated Y2H
32296183
Intra
KDM1A O60341 KRT33B Homo sapiens Q14525
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 GAS8 Homo sapiens O95995
Validated Y2H
32296183
Intra
KDM1A O60341 GAS8 Homo sapiens O95995
Y2H Array
32296183
Intra
KDM1A O60341 GAS8 Homo sapiens O95995
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 KRT35 Homo sapiens Q92764
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 KRT35 Homo sapiens Q92764
Validated Y2H
32296183
Intra
KDM1A O60341 KRT35 Homo sapiens Q92764
Y2H Array
32296183
Intra
KDM1A O60341 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra
KDM1A O60341 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra
KDM1A O60341 GOLGA6A Homo sapiens Q9NYA3
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 GOLGA6A Homo sapiens Q9NYA3
Validated Y2H
32296183
Intra
KDM1A O60341 GOLGA6A Homo sapiens Q9NYA3
Y2H Array
32296183
Intra
KDM1A O60341 CAGE1 Homo sapiens Q8TC20-4
Y2H Array
32296183
Intra
KDM1A O60341 CAGE1 Homo sapiens Q8TC20-4
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 CAGE1 Homo sapiens Q8TC20-4
Validated Y2H
32296183
Intra
KDM1A O60341 TLE5 Homo sapiens Q08117-2
Validated Y2H
32296183
Intra
KDM1A O60341 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra
KDM1A O60341 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 CEP57 Homo sapiens Q86XR8-3
Validated Y2H
32296183
Intra
KDM1A O60341 CEP57 Homo sapiens Q86XR8-3
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 CEP57 Homo sapiens Q86XR8-3
Y2H Array
32296183
Intra
KDM1A O60341 NR2E1 Homo sapiens Q9Y466
Anti Tag CoIP
36321378
Intra
KDM1A O60341 TP53BP2 Homo sapiens Q05BL1
Validated Y2H
32296183
Intra
KDM1A O60341 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
Intra
KDM1A O60341 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 KRT39 Homo sapiens Q6A163
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 KRT39 Homo sapiens Q6A163
Validated Y2H
32296183
Intra
KDM1A O60341 KRT39 Homo sapiens Q6A163
Y2H Array
32296183
Intra
KDM1A O60341 CCDC14 Homo sapiens Q49A88-3
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 CCDC14 Homo sapiens Q49A88-3
Validated Y2H
32296183
Intra
KDM1A O60341 CCDC14 Homo sapiens Q49A88-3
Y2H Array
32296183
Intra
KDM1A O60341 LZTS1 Homo sapiens Q9Y250
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 LZTS1 Homo sapiens Q9Y250
Validated Y2H
32296183
Intra
KDM1A O60341 LZTS1 Homo sapiens Q9Y250
Y2H Array
32296183
Intra
KDM1A O60341 TMEM266 Homo sapiens Q2M3C6
Validated Y2H
32296183
Intra
KDM1A O60341 RPRD1A Homo sapiens Q96P16-3
Y2H Array
32296183
Intra
KDM1A O60341 RPRD1A Homo sapiens Q96P16-3
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 RPRD1A Homo sapiens Q96P16-3
Validated Y2H
32296183
Intra
KDM1A O60341 UBASH3B Homo sapiens Q8TF42
Y2H Array
32296183
Intra
KDM1A O60341 UBASH3B Homo sapiens Q8TF42
Validated Y2H
32296183
Intra
KDM1A O60341 UBASH3B Homo sapiens Q8TF42
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 KIFC3 Homo sapiens Q9BVG8-5
Y2H Array
32296183
Intra
KDM1A O60341 KIFC3 Homo sapiens Q9BVG8-5
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
Intra
KDM1A O60341 RCOR3 Homo sapiens Q9P2K3-2
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 RCOR3 Homo sapiens Q9P2K3-2
Validated Y2H
32296183
Intra
KDM1A O60341 RCOR3 Homo sapiens Q9P2K3-2
Y2H Array
32296183
Intra
KDM1A O60341 JRK Homo sapiens O75564-2
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 JRK Homo sapiens O75564-2
Validated Y2H
32296183
Intra
KDM1A O60341 JRK Homo sapiens O75564-2
Y2H Array
32296183
Intra
KDM1A O60341 TNNT2 Homo sapiens P45379-11
Validated Y2H
32296183
Intra
KDM1A O60341 TNNT2 Homo sapiens P45379-11
Y2H Array
32296183
Intra
KDM1A O60341 TNNT2 Homo sapiens P45379-11
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 MBD3 Homo sapiens O95983
Anti Bait CoIP
19703393
Intra
KDM1A O60341 NFE2L2 Homo sapiens Q16236
Y2H Array
32296183
Intra
KDM1A O60341 NFE2L2 Homo sapiens Q16236
Validated Y2H
32296183
Intra
KDM1A O60341 NFE2L2 Homo sapiens Q16236
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 ELAVL4 Homo sapiens P26378-2
Validated Y2H
32814053
Intra
KDM1A O60341 ELAVL4 Homo sapiens P26378-2
Y2H Array
32814053
Intra
KDM1A O60341 ELAVL4 Homo sapiens P26378-2
Y2H Pooling
32814053
Intra
KDM1A O60341 PHF19 Homo sapiens Q5T6S3
Y2H
23455924
Intra
KDM1A O60341 PHF19 Homo sapiens Q5T6S3
Anti Tag CoIP
23455924
Intra
KDM1A O60341 SPICE1 Homo sapiens Q8N0Z3
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 SPICE1 Homo sapiens Q8N0Z3
Validated Y2H
32296183
Intra
KDM1A O60341 SPICE1 Homo sapiens Q8N0Z3
Y2H Array
32296183
Intra
KDM1A O60341 NRBF2 Homo sapiens Q96F24
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 NRBF2 Homo sapiens Q96F24
Validated Y2H
32296183
Intra
KDM1A O60341 NRBF2 Homo sapiens Q96F24
Y2H Array
32296183
Intra
KDM1A O60341 HAUS1 Homo sapiens Q96CS2
Y2H
23455924
Intra
KDM1A O60341 NBPF1 Homo sapiens Q3BBV0
Y2H Array
32296183
Intra
KDM1A O60341 NBPF1 Homo sapiens Q3BBV0
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 NBPF1 Homo sapiens Q3BBV0
Validated Y2H
32296183
Intra
KDM1A O60341 RASSF3 Homo sapiens Q86WH2
Validated Y2H
32296183
Intra
KDM1A O60341 FYCO1 Homo sapiens Q9BQS8
Anti Tag CoIP
23455924
Intra
KDM1A O60341 PFDN5 Homo sapiens Q99471
Y2H Array
32296183
Intra
KDM1A O60341 PFDN5 Homo sapiens Q99471
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 PFDN5 Homo sapiens Q99471
Validated Y2H
32296183
Intra
KDM1A O60341 PSMC1 Homo sapiens P62191
Anti Tag CoIP
23455924
Intra
KDM1A O60341 H3-4 Homo sapiens Q16695
Enzymatic Study
17537733
Intra
KDM1A O60341 TRAF4 Homo sapiens Q9BUZ4
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 TRAF4 Homo sapiens Q9BUZ4
Validated Y2H
32296183
Intra
KDM1A O60341 TRAF4 Homo sapiens Q9BUZ4
Y2H Array
32296183
Intra
KDM1A O60341 RASSF1 Homo sapiens Q9NS23
Anti Tag CoIP
23455924
Intra
KDM1A O60341 CDC5L Homo sapiens Q99459
Y2H
17043677
Intra
KDM1A O60341 CARD10 Homo sapiens Q9BWT7
Validated Y2H
32296183
Intra
KDM1A O60341 CARD10 Homo sapiens Q9BWT7
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 CARD10 Homo sapiens Q9BWT7
Y2H Array
32296183
Intra
KDM1A O60341 VPS37B Homo sapiens Q9H9H4
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 VPS37B Homo sapiens Q9H9H4
Validated Y2H
32296183
Intra
KDM1A O60341 VPS37B Homo sapiens Q9H9H4
Y2H Array
32296183
Intra
KDM1A O60341 MYC Homo sapiens P01106
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 MYC Homo sapiens P01106
Validated Y2H
32296183
Intra
KDM1A O60341 MYC Homo sapiens P01106
Y2H Array
32296183
Intra
KDM1A O60341 MYC Homo sapiens P01106
Y2H
23455924
Intra
KDM1A O60341 SERGEF Homo sapiens Q9UGK8
Y2H
23455924
Intra
KDM1A O60341 SERGEF Homo sapiens Q9UGK8
Anti Tag CoIP
23455924
Intra
KDM1A O60341 IMMT Homo sapiens Q16891
Y2H Pooling
16169070
Intra
KDM1A O60341 IMMT Homo sapiens Q16891
Pull Down
16169070
Intra
KDM1A O60341 BIRC2 Homo sapiens Q13490
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 BIRC2 Homo sapiens Q13490
Validated Y2H
32296183
Intra
KDM1A O60341 BIRC2 Homo sapiens Q13490
Y2H Array
32296183
Intra
KDM1A O60341 CHD3 Homo sapiens Q12873
Anti Bait CoIP
19703393
Intra
KDM1A O60341 ANKRD23 Homo sapiens Q86SG2
Validated Y2H
32296183
Intra
KDM1A O60341 ANKRD23 Homo sapiens Q86SG2
Y2H Array
32296183
Intra
KDM1A O60341 ANKRD23 Homo sapiens Q86SG2
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 HDAC3 Homo sapiens O15379
Anti Bait CoIP
23752268
Intra
KDM1A O60341 GTPBP2 Homo sapiens Q9BX10
Y2H
23455924
Intra
KDM1A O60341 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
KDM1A O60341 GOLGA2 Homo sapiens Q08379
Validated Y2H
32296183
Intra
KDM1A O60341 EXOC7 Homo sapiens Q9UPT5-1
Validated Y2H
32296183
Intra
KDM1A O60341 EXOC7 Homo sapiens Q9UPT5-1
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 EXOC7 Homo sapiens Q9UPT5-1
Y2H Array
32296183
Intra
KDM1A O60341 RBPJ Homo sapiens Q06330
TAP
25609649
Intra
KDM1A O60341 RBPJ Homo sapiens Q06330
Anti Tag CoIP
23022380
Intra
KDM1A O60341 NOTCH1 Homo sapiens P46531
Anti Tag CoIP
23022380
Intra
KDM1A O60341 HDAC1 Homo sapiens Q13547
Anti Bait CoIP
21258344
Intra
KDM1A O60341 RCOR1 Homo sapiens Q9UKL0
Anti Bait CoIP
20389281
Intra
KDM1A O60341 HDAC1 Homo sapiens Q13547
Anti Bait CoIP
19703393
Intra
KDM1A O60341 RCOR1 Homo sapiens Q9UKL0
Anti Bait CoIP
34031383
Intra
KDM1A O60341 RCOR1 Homo sapiens Q9UKL0
Pull Down
26226427
Intra
KDM1A O60341 RCOR1 Homo sapiens Q9UKL0
Enzymatic Study
17537733
Intra
KDM1A O60341 RCOR1 Homo sapiens Q9UKL0
Anti Bait CoIP
21258344
Intra
KDM1A O60341 WASHC3 Homo sapiens Q9Y3C0
Validated Y2H
32296183
Intra
KDM1A O60341 WASHC3 Homo sapiens Q9Y3C0
Y2H Array
32296183
Intra
KDM1A O60341 WASHC3 Homo sapiens Q9Y3C0
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 PELP1 Homo sapiens Q8IZL8
Pull Down
20448663
Intra
KDM1A O60341 PELP1 Homo sapiens Q8IZL8
Anti Bait CoIP
20448663
Intra
KDM1A O60341 FAM161A Homo sapiens Q3B820
Validated Y2H
32296183
Intra
KDM1A O60341 FAM161A Homo sapiens Q3B820
Y2H Array
32296183
Intra
KDM1A O60341 FAM161A Homo sapiens Q3B820
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 RCOR2 Homo sapiens Q8IZ40
Anti Bait CoIP
28420882
Intra
KDM1A O60341 KRT15 Homo sapiens P19012
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 KRT15 Homo sapiens P19012
Validated Y2H
32296183
Intra
KDM1A O60341 KRT15 Homo sapiens P19012
Y2H Array
32296183
Intra
KDM1A O60341 CEP70 Homo sapiens Q8NHQ1
Anti Tag CoIP
23455924
Intra
KDM1A O60341 ZBED1 Homo sapiens O96006
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 ZBED1 Homo sapiens O96006
Y2H Array
32296183
Intra
KDM1A O60341 ZBED1 Homo sapiens O96006
Validated Y2H
32296183
Intra
KDM1A O60341 CEP76 Homo sapiens Q8TAP6
Validated Y2H
32296183
Intra
KDM1A O60341 CEP76 Homo sapiens Q8TAP6
Y2H Array
32296183
Intra
KDM1A O60341 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 GCC1 Homo sapiens Q96CN9
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 GCC1 Homo sapiens Q96CN9
Y2H Array
32296183
Intra
KDM1A O60341 GCC1 Homo sapiens Q96CN9
Validated Y2H
32296183
Intra
KDM1A O60341 TEX9 Homo sapiens Q8N6V9
Validated Y2H
32296183
Intra
KDM1A O60341 TEX9 Homo sapiens Q8N6V9
Y2H Array
32296183
Intra
KDM1A O60341 TEX9 Homo sapiens Q8N6V9
Y2H
23455924
Intra
KDM1A O60341 TEX9 Homo sapiens Q8N6V9
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 SNF8 Homo sapiens Q96H20
Anti Tag CoIP
23455924
Intra
KDM1A O60341 HOMER3 Homo sapiens Q9NSC5
Validated Y2H
32296183
Intra
KDM1A O60341 HOMER3 Homo sapiens Q9NSC5
Y2H Array
32296183
Intra
KDM1A O60341 HOMER3 Homo sapiens Q9NSC5
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 SMAD9 Homo sapiens O15198
Y2H
23455924
Intra
KDM1A O60341 SMAD9 Homo sapiens O15198
Anti Tag CoIP
23455924
Intra
KDM1A O60341 SF3B2 Homo sapiens Q13435
Y2H
23455924
Intra
KDM1A O60341 SF3B2 Homo sapiens Q13435
Anti Tag CoIP
23455924
Intra
KDM1A O60341 LOXL4 Homo sapiens Q96JB6
Y2H
23455924
Intra
KDM1A O60341 ACE2 Homo sapiens Q9BYF1
Confocal
34031383
Intra
KDM1A O60341 ACE2 Homo sapiens Q9BYF1
Demethylase Assay
34031383
Intra
KDM1A O60341 NR1H3 Homo sapiens Q13133
Y2H
23455924
Intra
KDM1A O60341 FAM204A Homo sapiens Q9H8W3
Y2H Array
32296183
Intra
KDM1A O60341 FAM204A Homo sapiens Q9H8W3
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 FAM204A Homo sapiens Q9H8W3
Validated Y2H
32296183
Intra
KDM1A O60341 C8orf74 Homo sapiens Q6P047
Y2H
23455924
Intra
KDM1A O60341 ODAD3 Homo sapiens A5D8V7
Y2H
23455924
Intra
KDM1A O60341 ODAD3 Homo sapiens A5D8V7
Anti Tag CoIP
23455924
Intra
KDM1A O60341 FAM9A Homo sapiens Q8IZU1
Anti Tag CoIP
23455924
Intra
KDM1A O60341 FAM9A Homo sapiens Q8IZU1
Y2H
23455924
Intra
KDM1A O60341 HESX1 Homo sapiens Q9UBX0
Y2H
23455924
Intra
KDM1A O60341 KLHDC4 Homo sapiens Q8TBB5
Anti Tag CoIP
23455924
Intra
KDM1A O60341 OFCC1 Homo sapiens Q8IZS5
Y2H
23455924
Intra
KDM1A O60341 OFCC1 Homo sapiens Q8IZS5
Anti Tag CoIP
23455924
Intra
KDM1A O60341 STX19 Homo sapiens Q8N4C7
Y2H
23455924
Intra
KDM1A O60341 TTC23 Homo sapiens Q5W5X9-3
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 TTC23 Homo sapiens Q5W5X9-3
Validated Y2H
32296183
Intra
KDM1A O60341 TTC23 Homo sapiens Q5W5X9-3
Y2H Array
32296183
Intra
KDM1A O60341 COIL Homo sapiens P38432
Y2H Array
32296183
Intra
KDM1A O60341 COIL Homo sapiens P38432
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 COIL Homo sapiens P38432
Validated Y2H
32296183
Intra
KDM1A O60341 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
KDM1A O60341 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
Intra
KDM1A O60341 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra
KDM1A O60341 ZBTB39 Homo sapiens O15060
Y2H Array
32296183
Intra
KDM1A O60341 ZBTB39 Homo sapiens O15060
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KDM1A Proteins

Cat. No. Product Name Accession Purity
HY-P75551 LSD1 Protein, Human (sf9, His-GST) O60341-1 (S172-M852) ≥95%

KDM1A Antibodies

Cat. No. Product Name Application Reactivity
HY-P80731 KDM1A Antibody (YA718) WB Human, Mouse, Monkey

Related Diseases

Diseases Alias
Spherocytosis, Type 2

Hereditary Spherocytosis Type 2

SPH2

Spherocytosis, Hereditary, 2

Hs2

Hereditary Spherocytosis 2

Spherocytosis 2

Spherocytosis, Type 2, Autosomal Dominant
Cleft Palate, Psychomotor Retardation, And Distinctive Facial Features

Palatal Anomalies-Widely Spaced Teeth-Facial Dysmorphism-Developmental Delay Syndrome

CPRF

Palatal Anomalies-Multiple Diastemata-Facial Dysmorphism-Developmental Delay Syndrome
Rhabdomyosarcoma
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Leukemia, Myeloid, Acute

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Ewing Sarcoma

Neuroepithelioma

Ewing'S Tumor

Ewings Sarcoma

Ewing'S Sarcoma

Peripheral Neuroepithelioma

Primitive Neuroectodermal Tumor

ES

Ewings Sarcoma-Primitive Neuroectodermal Tumor

Localized Peripheral Primitive Neuroectodermal Tumor

Peripheral Primitive Neuroectodermal Tumor

Ewing Tumor

Sarcoma, Ewing'S

Extraosseous Ewing Tumor

Askin Tumor

Ewing'S Family Localized Tumor

Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing Sarcoma

Localized Ewing'S Sarcoma

Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing'S Tumor

Pnet Of Thoracopulmonary Region

Ewing Family Of Tumors

Tumor Of The Ewing Family

Skeletal Ewing Sarcoma

Osseous Ewing Sarcoma

Ppnet

Peripheral Pnet

Extraskeletal Ewing Sarcoma

Eoe

Extraosseous Ewing Sarcoma

Extraskeletal Ewing Tumor

Esft

Ewing Sarcoma Family Of Tumors

Pne

Pnet

Pnet Of The Chest Wall

Sarcoma, Ewing

Neuroectodermal Tumors, Primitive, Peripheral

Neuroectodermal Tumor, Primitive

Disorder Of Eye

Askin'S Tumor

Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

Neuroepithelioma, Peripheral
Myelodysplastic Syndrome

Myelodysplastic Syndromes

Myelodysplasia

MDS

Myelodysplastic Syndrome Included

Myelodysplastic Syndrome, Susceptibility To, Included

Myelodysplastic Syndrome, Somatic

Myelodysplastic Syndrome, Susceptibility To
Primary Hyperoxaluria

Hyperoxaluria, Primary

Oxalosis

Hyperoxaluria

Primary Oxalosis

Congenital Oxaluria

D-Glycerate Dehydrogenase Deficiency

Glyceric Aciduria

Glycolic Aciduria

Hepatic Agt Deficiency

Oxaluria, Primary

Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

Primary Oxaluria

Hyperoxaluria Primary

Primary Hyperoxaluria Type 2

Primary Hyperoxaluria, Type I
Cleft Palate, Cardiac Defects, And Mental Retardation

Cardiac Malformation, Cleft Lip/Palate, Microcephaly, And Digital Anomalies

CPCMR

Cleft Palate, Cardiac Defects, And Intellectual Disabillity

Cleft Palate, Cardiac Defects, And Intellectual Disability

Cardiac Malformation, Cleft Lip-Palate, Microcephaly And Digital Anomalies
Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Desmoplastic/Nodular Medulloblastoma

Medulloblastoma With Extensive Nodularity

Desmoplastic Medulloblastoma

Medulloblastoma, Somatic

Medulloblastoma, Desmoplastic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Mben

Medulloblastoma Desmoplastic

Neuroectodermal Tumors, Primitive

Medulloblastomas

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic
Kabuki Syndrome 1

Kabuki Syndrome

Niikawa-Kuroki Syndrome

Kabuki Make-Up Syndrome

Kms

KABUK1

Kabuki Make Up Syndrome

Nks

Kabuki Makeup Syndrome

Kabuki Syndrome, Type 1
Hutchinson-Gilford Progeria Syndrome

Progeria

HGPS

Hutchinson-Gilford Syndrome

Hutchinson-Gilford Progeria

Hutchinson Gilford Syndrome

Hutchinson-Gilford Disease

Hutchinson Gilford Progeria Syndrome

Progeria Of Childhood

Hutchinson-Gilford-Progeria Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-18632 GSK2879552 Inhibitor 99.90% Phase 2
HY-103713 Seclidemstat Inhibitor 99.77% Phase 2
HY-18632A GSK2879552 dihydrochloride Inhibitor 99.19% Phase 2
HY-109117 Iadademstat Inhibitor 99.61% Phase 2
HY-12782T Iadademstat dihydrochloride Inhibitor 99.98% Phase 1
HY-138830 TAK-418 Inhibitor 99.10% Phase 1
Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-103713A Seclidemstat mesylate Inhibitor 99.60% Unkown
HY-19612B DDP-38003 trihydrochloride Inhibitor / Unkown
HY-19612A DDP-38003 dihydrochloride Inhibitor 98.22% Unkown
HY-112304 NCD38 TFA Inhibitor / Unkown
HY-112304A (1R,2S)-NCD38 TFA Inhibitor / Unkown
HY-143238 FY-56 Inhibitor / Unkown
HY-RS07205 KDM1A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS07206 Kdm1a Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS07207 Kdm1a Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus KDM1A RGD RGD:1562975
Canis familiaris KDM1A VGNC VGNC:42318
Bos taurus KDM1A VGNC VGNC:30522
Mus musculus KDM1A MGD MGI:1196256
Macaca mulatta KDM1A VGNC VGNC:73928
Felis catus KDM1A VGNC VGNC:63067
Others KDM1A NCBI