Gentisuric acid

Cat. No.: HY-W338852 Purity: 99.65%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Gentisuric acid, a metabolite of Aspirin (HY-14654), is a substrate of α-amidating monooxygenase (PAM). Gentisuric acid prevents DNA-damage by Mitomycin C (HY-13316).

For research use only. We do not sell to patients.

Gentisuric acid Chemical Structure

CAS No. : 25351-24-0

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
50 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
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Description

Gentisuric acid, a metabolite of Aspirin (HY-14654), is a substrate of α-amidating monooxygenase (PAM). Gentisuric acid prevents DNA-damage by Mitomycin C (HY-13316)^[1]^[2].

Molecular Weight

211.17

Formula

C₉H₉NO₅

CAS No.

25351-24-0

Appearance

Solid

Color

White to off-white

SMILES

OC1=CC(C(NCC(O)=O)=O)=C(O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 83.33 mg/mL (394.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.7355 mL	23.6776 mL	47.3552 mL
5 mM	0.9471 mL	4.7355 mL	9.4710 mL
10 mM	0.4736 mL	2.3678 mL	4.7355 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.65%

Select Batch:

Data Sheet (270 KB) SDS (614 KB)

COA (246 KB) HNMR (247 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. DeBlassio JL, et al. Amidation of salicyluric acid and gentisuric acid: a possible role for peptidylglycine alpha-amidating monooxygenase in the metabolism of aspirin. Arch Biochem Biophys. 2000 Nov 1;383(1):46-55. [Content Brief]

[2]. Niikawa M, et al. Suppressive effect of post- or pre-treatment of aspirin metabolite on mitomycin C-induced genotoxicity using the somatic mutation and recombination test in Drosophila melanogaster. Biomed Pharmacother. 2007 Feb-Apr;61(2-3):113-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.7355 mL	23.6776 mL	47.3552 mL	118.3880 mL
	5 mM	0.9471 mL	4.7355 mL	9.4710 mL	23.6776 mL
	10 mM	0.4736 mL	2.3678 mL	4.7355 mL	11.8388 mL
	15 mM	0.3157 mL	1.5785 mL	3.1570 mL	7.8925 mL
	20 mM	0.2368 mL	1.1839 mL	2.3678 mL	5.9194 mL
	25 mM	0.1894 mL	0.9471 mL	1.8942 mL	4.7355 mL
	30 mM	0.1579 mL	0.7893 mL	1.5785 mL	3.9463 mL
	40 mM	0.1184 mL	0.5919 mL	1.1839 mL	2.9597 mL
	50 mM	0.0947 mL	0.4736 mL	0.9471 mL	2.3678 mL
	60 mM	0.0789 mL	0.3946 mL	0.7893 mL	1.9731 mL
	80 mM	0.0592 mL	0.2960 mL	0.5919 mL	1.4799 mL
	100 mM	0.0474 mL	0.2368 mL	0.4736 mL	1.1839 mL

Gentisuric acid Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gentisuric acid25351-24-0Drug Metaboliteaspirin metabolismα-amidating monooxygenaseDNA-damageInhibitorinhibitorinhibit

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