2. Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Thyroid Hormone Receptor Endogenous Metabolite
  4. (Glu2)-TRH

(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS.

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(Glu2)-TRH Chemical Structure

(Glu2)-TRH Chemical Structure

CAS No. : 85541-78-2

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Based on 1 publication(s) in Google Scholar

(Glu2)-TRH Related Antibodies

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Description

(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS[1].

In Vivo

(Glu2)-TRH (1-100 μmol/kg; IV) dose-dependently attenuated TRH-induced analeptic action[1].
(Glu2)-TRH (10 μmol/kg; IV) 10 min before Pentobarbital (60 mg/kg; i.p.) decreases the sleeping time by approximately 20% compared to the vehicle treated group[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss-Webster mice (30 g)[1]
Dosage: 1, 2, 5, 10, 15, 25, 50, 100 μmol/kg
Administration: IV; 10 min before Pentobarbital (60 mg/kg, i.p.)
Result: Dose-dependently attenuated TRH-induced (10 μmol/kg; iv) analeptic action.
Molecular Weight

354.36

Formula

C15H22N4O6
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

Glp-EP-NH2
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (282.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8220 mL 14.1099 mL 28.2199 mL
5 mM 0.5644 mL 2.8220 mL 5.6440 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8220 mL 14.1099 mL 28.2199 mL 70.5497 mL
5 mM 0.5644 mL 2.8220 mL 5.6440 mL 14.1099 mL
10 mM 0.2822 mL 1.4110 mL 2.8220 mL 7.0550 mL
15 mM 0.1881 mL 0.9407 mL 1.8813 mL 4.7033 mL
20 mM 0.1411 mL 0.7055 mL 1.4110 mL 3.5275 mL
25 mM 0.1129 mL 0.5644 mL 1.1288 mL 2.8220 mL
30 mM 0.0941 mL 0.4703 mL 0.9407 mL 2.3517 mL
40 mM 0.0705 mL 0.3527 mL 0.7055 mL 1.7637 mL
50 mM 0.0564 mL 0.2822 mL 0.5644 mL 1.4110 mL
60 mM 0.0470 mL 0.2352 mL 0.4703 mL 1.1758 mL
80 mM 0.0353 mL 0.1764 mL 0.3527 mL 0.8819 mL
100 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.7055 mL
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(Glu2)-TRH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Glu2)-TRH85541-78-2Thyroid Hormone ReceptorEndogenous MetaboliteTHRThyrotropin-releasing hormoneTRHcholinergichippocampalacetylcholineneuroprotectiveantidepressantanticonvulsanCNSInhibitorinhibitorinhibit

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