2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor Antibody-drug Conjugate/ADC Related
  3. Glucocorticoid Receptor ADC Cytotoxin
  4. Glucocorticoid receptor agonist-2

Glucocorticoid receptor agonist-2 

Cat. No.: HY-148435 Purity: 99.65%
COA Handling Instructions

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Glucocorticoid receptor agonist-2 (compound 21) is an glucocorticoid receptor agonist with an IC50 value of 6.6 nM. Glucocorticoid receptor agonist-2 can be used to synthesize anti-inflammatory ADC molecules. Glucocorticoid receptor agonist-2 is an active reference of ABBV-3373.

For research use only. We do not sell to patients.

Glucocorticoid receptor agonist-2 Chemical Structure

Glucocorticoid receptor agonist-2 Chemical Structure

CAS No. : 2166378-92-1

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1 mg USD 370 In-stock
5 mg USD 850 In-stock
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Based on 1 publication(s) in Google Scholar

Glucocorticoid receptor agonist-2 Related Antibodies

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Description

Glucocorticoid receptor agonist-2 (compound 21) is an glucocorticoid receptor agonist with an IC50 value of 6.6 nM. Glucocorticoid receptor agonist-2 can be used to synthesize anti-inflammatory ADC molecules. Glucocorticoid receptor agonist-2 is an active reference of ABBV-3373[1].

In Vitro

Glucocorticoid receptor agonist-2 shows glucocorticoid receptor (GR) and progersterone receptor (PR) binding activities with IC50 values of 6.6 and 7.3 nM, respectively[1].
Glucocorticoid receptor agonist-2 shows EC50 values of 0.2 and 442 nM to glucocorticoid responsive element (GRE) reporter and mineralcorticoid receptor (MR), respectively[1].
Glucocorticoid receptor agonist-2 agonists MR with an EC50 value of 149 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glucocorticoid receptor agonist-2 Related Antibodies
Molecular Weight

607.64

Formula

C34H35F2NO7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[H][C@]1(C[C@]2(O[C@H](O[C@]23C(CO)=O)C4=CC=C(OC5=CC(N)=CC=C5)C=C4)[H])[C@@]6(C[C@@H](C7=CC(C=C[C@@]7([C@](F)6[C@@H](O)C[C@@]13C)C)=O)F)[H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (20.57 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6457 mL 8.2286 mL 16.4571 mL
5 mM 0.3291 mL 1.6457 mL 3.2914 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.65%

COA (252 KB) HNMR (379 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6457 mL 8.2286 mL 16.4571 mL 41.1428 mL
5 mM 0.3291 mL 1.6457 mL 3.2914 mL 8.2286 mL
10 mM 0.1646 mL 0.8229 mL 1.6457 mL 4.1143 mL
15 mM 0.1097 mL 0.5486 mL 1.0971 mL 2.7429 mL
20 mM 0.0823 mL 0.4114 mL 0.8229 mL 2.0571 mL
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Glucocorticoid receptor agonist-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glucocorticoid receptor agonist-22166378-92-1Glucocorticoid receptor agonist2Glucocorticoid receptor agonist 2Glucocorticoid ReceptorADC CytotoxinADC PayloadABBV-3373referenceADCglucocorticoid receptorprogersterone receptorInhibitorinhibitorinhibit

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