2. Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Cytoskeleton Epigenetics Neuronal Signaling
  3. ROCK Aurora Kinase CaMK
  4. Glycyl H-1152 hydrochloride

Glycyl H-1152 hydrochloride (compound 18) is a glycyl derivative of Rho-kinase inhibitors H-1152 dihydrochloride. Glycyl H-1152 hydrochloride inhibits ROCKII, Aurora A, CAMKII and PKG, with IC50s of 0.0118, 2.35, 2.57 and 3.26 μM respectively. Glycyl H-1152 hydrochloride has higher selective than H-1152 hydrochloride.

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Glycyl H-1152 hydrochloride Chemical Structure

Glycyl H-1152 hydrochloride Chemical Structure

CAS No. : 913844-45-8

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Based on 1 publication(s) in Google Scholar

Other Forms of Glycyl H-1152 hydrochloride:

Glycyl H-1152 hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All ROCK Isoform Specific Products:

View All Isoforms
ROCK ROCK1 ROCK2

View All Aurora Kinase Isoform Specific Products:

View All Isoforms
Aurora Kinase Aurora A Aurora B Aurora C

View All CaMK Isoform Specific Products:

View All Isoforms
CaMK III CaMK II

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Description

Glycyl H-1152 hydrochloride (compound 18) is a glycyl derivative of Rho-kinase inhibitors H-1152 dihydrochloride. Glycyl H-1152 hydrochloride inhibits ROCKII, Aurora A, CAMKII and PKG, with IC50s of 0.0118, 2.35, 2.57 and 3.26 μM respectively. Glycyl H-1152 hydrochloride has higher selective than H-1152 hydrochloride[1].

IC50 & Target[1]

ROCKII

11.8 nM (IC50)

Aurora A

2.35 μM (IC50)

CaMK II

2.57 μM (IC50)

PKG

3.26 μM (IC50)

Molecular Weight

449.40

Formula

C18H26Cl2N4O3S
CAS No.
SMILES

O=S(N1[C@@H](C)CN(C(CN)=O)CCC1)(C2=CC=CC3=C2C(C)=CN=C3)=O.[H]Cl.[H]Cl
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Glycyl H-1152 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glycyl H-1152913844-45-8Glycyl H1152Glycyl H 1152ROCKAurora KinaseCaMKRho-associated protein kinaseRho-associated kinaseRho-kinaseROKCalmodulin-dependent protein kinasesCalmodulin-dependent kinasesglycylderivativeROCKIIAurora ACAMKIIPKGInhibitorinhibitorinhibit

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