2. GPCR/G Protein
  3. GPR6
  4. (S)-CVN424

(S)-CVN424 is a potent G-Protein-Coupled Receptor 6 (GPR6) modulator. (S)-CVN424 has the potential for a variety of neurological and psychiatric disorders research, including Parkinson's disease.

For research use only. We do not sell to patients.

(S)-CVN424 Chemical Structure

(S)-CVN424 Chemical Structure

CAS No. : 1799968-74-3

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5 mg USD 450 In-stock
10 mg USD 720 In-stock
25 mg USD 1300 In-stock
50 mg USD 1820 In-stock
100 mg USD 2550 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (S)-CVN424:

(S)-CVN424 Related Antibodies

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Description

(S)-CVN424 is a potent G-Protein-Coupled Receptor 6 (GPR6) modulator. (S)-CVN424 has the potential for a variety of neurological and psychiatric disorders research, including Parkinson's disease[1].

IC50 & Target

GPR6[1]
In Vitro

(S)-CVN424 (example 149) inhibits cAMP activity with an IC50 of 58.7 μM in CHO-K1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S)-CVN424 Related Antibodies
Molecular Weight

473.52

Formula

C24H29F2N5O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(N1CCC2=NC(N3CCC(OC4=CC=C(F)C=C4F)CC3)=C(N[C@@H]5COCC5)N=C2C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (52.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1118 mL 10.5592 mL 21.1184 mL
5 mM 0.4224 mL 2.1118 mL 4.2237 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1118 mL 10.5592 mL 21.1184 mL 52.7961 mL
5 mM 0.4224 mL 2.1118 mL 4.2237 mL 10.5592 mL
10 mM 0.2112 mL 1.0559 mL 2.1118 mL 5.2796 mL
15 mM 0.1408 mL 0.7039 mL 1.4079 mL 3.5197 mL
20 mM 0.1056 mL 0.5280 mL 1.0559 mL 2.6398 mL
25 mM 0.0845 mL 0.4224 mL 0.8447 mL 2.1118 mL
30 mM 0.0704 mL 0.3520 mL 0.7039 mL 1.7599 mL
40 mM 0.0528 mL 0.2640 mL 0.5280 mL 1.3199 mL
50 mM 0.0422 mL 0.2112 mL 0.4224 mL 1.0559 mL
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(S)-CVN424 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-CVN4241799968-74-3GPR6G Protein-Coupled Receptor 6CHO-K1G-Protein-CoupledReceptorInhibitorinhibitorinhibit

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