2. PI3K/Akt/mTOR Stem Cell/Wnt
  3. GSK-3
  4. GSK-3β inhibitor 14

GSK-3β inhibitor 14 (Compound 6i), benzothiazepinone derivative, is a weak GSK-3β inhibitor (IC50 >100 μM).

For research use only. We do not sell to patients.

GSK-3β inhibitor 14 Chemical Structure

GSK-3β inhibitor 14 Chemical Structure

CAS No. : 863004-48-2

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5 mg USD 210 In-stock
10 mg USD 320 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

GSK-3β inhibitor 14 (Compound 6i), benzothiazepinone derivative, is a weak GSK-3β inhibitor (IC50 >100 μM)[1].

Molecular Weight

283.39

Formula

C17H17NOS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1CC(C)SC2=CC=CC=C2N1CC3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (352.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5287 mL 17.6435 mL 35.2871 mL
5 mM 0.7057 mL 3.5287 mL 7.0574 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5287 mL 17.6435 mL 35.2871 mL 88.2176 mL
5 mM 0.7057 mL 3.5287 mL 7.0574 mL 17.6435 mL
10 mM 0.3529 mL 1.7644 mL 3.5287 mL 8.8218 mL
15 mM 0.2352 mL 1.1762 mL 2.3525 mL 5.8812 mL
20 mM 0.1764 mL 0.8822 mL 1.7644 mL 4.4109 mL
25 mM 0.1411 mL 0.7057 mL 1.4115 mL 3.5287 mL
30 mM 0.1176 mL 0.5881 mL 1.1762 mL 2.9406 mL
40 mM 0.0882 mL 0.4411 mL 0.8822 mL 2.2054 mL
50 mM 0.0706 mL 0.3529 mL 0.7057 mL 1.7644 mL
60 mM 0.0588 mL 0.2941 mL 0.5881 mL 1.4703 mL
80 mM 0.0441 mL 0.2205 mL 0.4411 mL 1.1027 mL
100 mM 0.0353 mL 0.1764 mL 0.3529 mL 0.8822 mL
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GSK-3β inhibitor 14 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK-3β inhibitor 14863004-48-2GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3BenzothiazepinonesdiabetesAlzheimer’s diseaseInhibitorinhibitorinhibit

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