2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. GSK_WRN4

GSK_WRN4 is a WRN helicase inhibitor (pIC50=7.6) with anticancer activity. GSK_WRN4 selectively inhibits the growth of MSI tumor cells in vitro and in vivo by inducing DNA double-strand breaks, particularly at expanded TA repeats and DNA damage regions.

For research use only. We do not sell to patients.

GSK_WRN4 Chemical Structure

GSK_WRN4 Chemical Structure

CAS No. : 2923008-66-4

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GSK_WRN4 Related Antibodies

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Description

GSK_WRN4 is a WRN helicase inhibitor (pIC50=7.6) with anticancer activity. GSK_WRN4 selectively inhibits the growth of MSI tumor cells in vitro and in vivo by inducing DNA double-strand breaks, particularly at expanded TA repeats and DNA damage regions[1].

Molecular Weight

336.41

Formula

C16H20N2O4S
CAS No.
SMILES

O=C1NC(C2CCCCC2)=CC=C1C(N[C@@H]3C=CS(=O)(C3)=O)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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GSK_WRN4 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK_WRN42923008-66-4DNA/RNA SynthesisWRNinhibitoranticancerMSIDNA fragmentationInhibitorinhibit

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