GSK737

Cat. No.: HY-153241 Purity: 99.89%: FAQs
Data Sheet SDS COA Handling Instructions

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GSK737 is a BRD4 BD1 and BD2 inhibitor, with pIC₅₀ values of 5.3 and 7.3 respectively. GSK737 has low clearance and good solubility and permeability in rat.

For research use only. We do not sell to patients.

GSK737 Chemical Structure

CAS No. : 2748687-95-6

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GSK737 Related Antibodies

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Description

GSK737 is a BRD4 BD1 and BD2 inhibitor, with pIC₅₀ values of 5.3 and 7.3 respectively. GSK737 has low clearance and good solubility and permeability in rat^[1].

Molecular Weight
363.41

Formula
C₂₀H₂₁N₅O₂

CAS No.
2748687-95-6

Appearance

Solid

Color

White to off-white

SMILES
C[C@@H](C1=CC=CC=N1)OC2=C(C3=CN(C)N=N3)C=C(C=C2)C(NC4CC4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder -20°C 3 years

4°C 2 years

In solvent -80°C 6 months

-20°C 1 month

Solvent & Solubility
In Vitro:

DMSO : 100 mg/mL (275.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass 1 mg 5 mg 10 mg

1 mM 2.7517 mL 13.7586 mL 27.5171 mL

5 mM 0.5503 mL 2.7517 mL 5.5034 mL

10 mM 0.2752 mL 1.3759 mL 2.7517 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass

=
Concentration

×
Volume

×
Molecular Weight *

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

C1

×
Volume _(start)

V1

=
Concentration _(final)

C2

×
Volume _(final)

V2

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage
mg/kg

Animal weight
(per animal)
g

Dosing volume
(per animal)
μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.89%
Select Batch:

Data Sheet (271 KB) SDS (251 KB)
COA (252 KB) HNMR (143 KB) RP-HPLC (169 KB) LCMS (386 KB)
Handling Instructions (2659 KB)

References

[1]. Aylott HE, et al. Template-Hopping Approach Leads to Potent, Selective, and Highly Soluble Bromo and Extraterminal Domain (BET) Second Bromodomain (BD2) Inhibitors. J Med Chem. 2021 Mar 25;64(6):3249-3281. [Content Brief]

[1]. Aylott HE, et al. Template-Hopping Approach Leads to Potent, Selective, and Highly Soluble Bromo and Extraterminal Domain (BET) Second Bromodomain (BD2) Inhibitors. J Med Chem. 2021 Mar 25;64(6):3249-3281.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg

DMSO 1 mM 2.7517 mL 13.7586 mL 27.5171 mL 68.7928 mL

5 mM 0.5503 mL 2.7517 mL 5.5034 mL 13.7586 mL

10 mM 0.2752 mL 1.3759 mL 2.7517 mL 6.8793 mL

15 mM 0.1834 mL 0.9172 mL 1.8345 mL 4.5862 mL

20 mM 0.1376 mL 0.6879 mL 1.3759 mL 3.4396 mL

25 mM 0.1101 mL 0.5503 mL 1.1007 mL 2.7517 mL

30 mM 0.0917 mL 0.4586 mL 0.9172 mL 2.2931 mL

40 mM 0.0688 mL 0.3440 mL 0.6879 mL 1.7198 mL

50 mM 0.0550 mL 0.2752 mL 0.5503 mL 1.3759 mL

60 mM 0.0459 mL 0.2293 mL 0.4586 mL 1.1465 mL

80 mM 0.0344 mL 0.1720 mL 0.3440 mL 0.8599 mL

100 mM 0.0275 mL 0.1376 mL 0.2752 mL 0.6879 mL

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GSK737 Related Classifications

Cancer

Cancer Targeted Therapy Cancer Metabolism and Metastasis

Epigenetics

Epigenetic Reader Domain

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK7372748687-95-6GSK 737GSK-737Epigenetic Reader DomainBETratlow clearanceInhibitorinhibitorinhibit

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Size		Stock
5 mg		Check price and availability
10 mg		Check price and availability

DMSO	1 mM	2.7517 mL	13.7586 mL	27.5171 mL	68.7928 mL
	5 mM	0.5503 mL	2.7517 mL	5.5034 mL	13.7586 mL
	10 mM	0.2752 mL	1.3759 mL	2.7517 mL	6.8793 mL
	15 mM	0.1834 mL	0.9172 mL	1.8345 mL	4.5862 mL
	20 mM	0.1376 mL	0.6879 mL	1.3759 mL	3.4396 mL
	25 mM	0.1101 mL	0.5503 mL	1.1007 mL	2.7517 mL
	30 mM	0.0917 mL	0.4586 mL	0.9172 mL	2.2931 mL
	40 mM	0.0688 mL	0.3440 mL	0.6879 mL	1.7198 mL
	50 mM	0.0550 mL	0.2752 mL	0.5503 mL	1.3759 mL
	60 mM	0.0459 mL	0.2293 mL	0.4586 mL	1.1465 mL
	80 mM	0.0344 mL	0.1720 mL	0.3440 mL	0.8599 mL
	100 mM	0.0275 mL	0.1376 mL	0.2752 mL	0.6879 mL

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GSK737

GSK737 Related Antibodies

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Complete Stock Solution Preparation Table

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