2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. GTX-758

GTX-758 is an orally active, nonsteroidal, selective agonist of ERα. GTX-758 plays an important role in castration resistant prostate cancer (CRPC) research.

For research use only. We do not sell to patients.

GTX-758 Chemical Structure

GTX-758 Chemical Structure

CAS No. : 938067-78-8

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Based on 1 publication(s) in Google Scholar

GTX-758 Related Antibodies

Top Publications Citing Use of Products

View All Estrogen Receptor/ERR Isoform Specific Products:

View All Isoforms
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

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Description

GTX-758 is an orally active, nonsteroidal, selective agonist of ERα. GTX-758 plays an important role in castration resistant prostate cancer (CRPC) research[1].

IC50 & Target

ERα

 

Molecular Weight

341.31

Formula

C19H13F2NO3
CAS No.
SMILES

O=C(N(C1=CC=C(F)C=C1)C2=CC=C(O)C=C2)C3=CC=C(O)C(F)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (292.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9299 mL 14.6494 mL 29.2989 mL
5 mM 0.5860 mL 2.9299 mL 5.8598 mL
View the Complete Stock Solution Preparation Table

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9299 mL 14.6494 mL 29.2989 mL 73.2472 mL
5 mM 0.5860 mL 2.9299 mL 5.8598 mL 14.6494 mL
10 mM 0.2930 mL 1.4649 mL 2.9299 mL 7.3247 mL
15 mM 0.1953 mL 0.9766 mL 1.9533 mL 4.8831 mL
20 mM 0.1465 mL 0.7325 mL 1.4649 mL 3.6624 mL
25 mM 0.1172 mL 0.5860 mL 1.1720 mL 2.9299 mL
30 mM 0.0977 mL 0.4883 mL 0.9766 mL 2.4416 mL
40 mM 0.0732 mL 0.3662 mL 0.7325 mL 1.8312 mL
50 mM 0.0586 mL 0.2930 mL 0.5860 mL 1.4649 mL
60 mM 0.0488 mL 0.2442 mL 0.4883 mL 1.2208 mL
80 mM 0.0366 mL 0.1831 mL 0.3662 mL 0.9156 mL
100 mM 0.0293 mL 0.1465 mL 0.2930 mL 0.7325 mL
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GTX-758 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GTX-758938067-78-8GTX758GTX 758Estrogen Receptor/ERRcastration resistant prostate cancerInhibitorinhibitorinhibit

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