2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Guanfacine

Guanfacine is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD).

For research use only. We do not sell to patients.

Guanfacine Chemical Structure

Guanfacine Chemical Structure

CAS No. : 29110-47-2

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Based on 2 publication(s) in Google Scholar

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Guanfacine Related Antibodies

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α adrenergic receptor β adrenergic receptor

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Description

Guanfacine is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD)[1][2][3].

IC50 & Target

α adrenergic receptor

 

In Vitro

Guanfacine increases the delay-related neuronal firing needed for working memory on dIPFC neurons at the cellular level[1][3].
Guanfacine improves PFC cognitive function by inhibiting the production of CAMP, closing HCN channels, and strengthening the PFC networks[1][3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Guanfacine Related Antibodies
In Vivo

Guanfacine enhances PFC working memory function in aged monkeys and improves impulse control in monkeys performing a delayed discounting task[1][3].
Guanfacine improves cognitive performance when infused directly into the rat or monkey PFC[1][3].
Guanfacine blocks 2A receptors in the monkey dIPFC markedly impairs working memory, behavioral inhibition and greatly reduces persistent neuronal firing[1][3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

246.09

Formula

C9H9Cl2N3O
CAS No.
SMILES

O=C(NC(N)=N)CC1=C(Cl)C=CC=C1Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Guanfacine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Guanfacine29110-47-2Adrenergic ReceptorBeta Receptornoradrenergic α2Aα2A receptorhypotensionsedationprefrontal cortex (PFC)cognitive disorderstourette's syndromeattention deficit hyperactivity disorder (ADHD)Inhibitorinhibitorinhibit

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