2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Guanfacine

Guanfacine is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD).

For research use only. We do not sell to patients.

Guanfacine Chemical Structure

Guanfacine Chemical Structure

CAS No. : 29110-47-2

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Based on 2 publication(s) in Google Scholar

Other Forms of Guanfacine:

Guanfacine Related Antibodies

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α adrenergic receptor β adrenergic receptor

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Description

Guanfacine is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD)[1][2][3].

IC50 & Target

α adrenergic receptor

 

In Vitro

Guanfacine increases the delay-related neuronal firing needed for working memory on dIPFC neurons at the cellular level[1][3].
Guanfacine improves PFC cognitive function by inhibiting the production of CAMP, closing HCN channels, and strengthening the PFC networks[1][3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Guanfacine Related Antibodies
In Vivo

Guanfacine enhances PFC working memory function in aged monkeys and improves impulse control in monkeys performing a delayed discounting task[1][3].
Guanfacine improves cognitive performance when infused directly into the rat or monkey PFC[1][3].
Guanfacine blocks 2A receptors in the monkey dIPFC markedly impairs working memory, behavioral inhibition and greatly reduces persistent neuronal firing[1][3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

246.09

Formula

C9H9Cl2N3O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC(N)=N)CC1=C(Cl)C=CC=C1Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (507.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0636 mL 20.3178 mL 40.6355 mL
5 mM 0.8127 mL 4.0636 mL 8.1271 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0636 mL 20.3178 mL 40.6355 mL 101.5889 mL
5 mM 0.8127 mL 4.0636 mL 8.1271 mL 20.3178 mL
10 mM 0.4064 mL 2.0318 mL 4.0636 mL 10.1589 mL
15 mM 0.2709 mL 1.3545 mL 2.7090 mL 6.7726 mL
20 mM 0.2032 mL 1.0159 mL 2.0318 mL 5.0794 mL
25 mM 0.1625 mL 0.8127 mL 1.6254 mL 4.0636 mL
30 mM 0.1355 mL 0.6773 mL 1.3545 mL 3.3863 mL
40 mM 0.1016 mL 0.5079 mL 1.0159 mL 2.5397 mL
50 mM 0.0813 mL 0.4064 mL 0.8127 mL 2.0318 mL
60 mM 0.0677 mL 0.3386 mL 0.6773 mL 1.6931 mL
80 mM 0.0508 mL 0.2540 mL 0.5079 mL 1.2699 mL
100 mM 0.0406 mL 0.2032 mL 0.4064 mL 1.0159 mL
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Guanfacine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Guanfacine29110-47-2Adrenergic ReceptorBeta Receptornoradrenergic α2Aα2A receptorhypotensionsedationprefrontal cortex (PFC)cognitive disorderstourette's syndromeattention deficit hyperactivity disorder (ADHD)Inhibitorinhibitorinhibit

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