2. Metabolic Enzyme/Protease Membrane Transporter/Ion Channel
  3. Endogenous Metabolite Potassium Channel
  4. Guanosine 5'-diphosphate (sodium), 96% (HPLC)

Guanosine 5'-diphosphate (sodium), 96% (HPLC)  (Synonyms: GDP (sodium), Type I, 96% (HPLC))

Cat. No.: HY-113066C Purity: 99.88%
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Guanosine 5'-diphosphate (sodium), 96% (HPLC) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate sodium, Type I, 96% (HPLC) is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate (sodium), 96% (HPLC) can be used in the research of inflammation, such as anemia of inflammation (AI).

For research use only. We do not sell to patients.

Guanosine 5'-diphosphate (sodium), 96% (HPLC) Chemical Structure

Guanosine 5'-diphosphate (sodium), 96% (HPLC) Chemical Structure

CAS No. : 43139-22-6

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Based on 2 publication(s) in Google Scholar

Other Forms of Guanosine 5'-diphosphate (sodium), 96% (HPLC):

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2 Publications Citing Use of MCE Guanosine 5'-diphosphate (sodium), 96% (HPLC)

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Description

Guanosine 5'-diphosphate (sodium), 96% (HPLC) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate sodium, Type I, 96% (HPLC) is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate (sodium), 96% (HPLC) can be used in the research of inflammation, such as anemia of inflammation (AI)[1][2].

IC50 & Target

K+ channel[1], endogenous metabolite[2].
Clinical Trial
Molecular Weight

465.18

Formula

C10H14N5NaO11P2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=P(OP(O)(O[Na])=O)(O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(N)NC3=O)=C3N=C2)O1
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (214.97 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1497 mL 10.7485 mL 21.4971 mL
5 mM 0.4299 mL 2.1497 mL 4.2994 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

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=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.1497 mL 10.7485 mL 21.4971 mL 53.7426 mL
5 mM 0.4299 mL 2.1497 mL 4.2994 mL 10.7485 mL
10 mM 0.2150 mL 1.0749 mL 2.1497 mL 5.3743 mL
15 mM 0.1433 mL 0.7166 mL 1.4331 mL 3.5828 mL
20 mM 0.1075 mL 0.5374 mL 1.0749 mL 2.6871 mL
25 mM 0.0860 mL 0.4299 mL 0.8599 mL 2.1497 mL
30 mM 0.0717 mL 0.3583 mL 0.7166 mL 1.7914 mL
40 mM 0.0537 mL 0.2687 mL 0.5374 mL 1.3436 mL
50 mM 0.0430 mL 0.2150 mL 0.4299 mL 1.0749 mL
60 mM 0.0358 mL 0.1791 mL 0.3583 mL 0.8957 mL
80 mM 0.0269 mL 0.1344 mL 0.2687 mL 0.6718 mL
100 mM 0.0215 mL 0.1075 mL 0.2150 mL 0.5374 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Guanosine 5'-diphosphate (sodium), 96% (HPLC) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Guanosine 5'-diphosphate (sodium), 96% (HPLC)43139-22-6GDP (sodium), Type I, 96% (HPLC)Endogenous MetabolitePotassium ChannelKcsAK+ channelIL-6/stat-3 pathwayhepcidininflammationanemiaAICaco-2HepG2Inhibitorinhibitorinhibit

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