H-Tyr-Tyr-OH (Synonyms: L-Tyrosyl-L-tyrosine)

Name: H-Tyr-Tyr-OH
Brand: MedChemExpress
SKU: HY-114782
Rating: 4.5 (1 reviews)

Cat. No.: HY-114782 Purity: ≥97.0%: FAQs
Data Sheet SDS COA Handling Instructions

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H-Tyr-Tyr-OH (L-Tyrosyl-L-tyrosine) is an antihypertensive peptide. H-Tyr-Tyr-OH inhibits angiotensin I-converting enzyme (ACE) with an IC₅₀ value of 0.028 mg/mL. H-Tyr-Tyr-OH can be used for the research of high blood pressure.

For research use only. We do not sell to patients.

H-Tyr-Tyr-OH Chemical Structure

CAS No. : 1050-28-8

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100 mg	USD 125	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

IC₅₀ & Target

IC50: 0.028 mg/mL (ACE)^[2]

In Vitro

H-Tyr-Tyr-OH shows inhibitory effect against ACE with an IC₅₀ value of 0.028 mg/mL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

H-Tyr-Tyr-OH (12.5 mg/kg; intraarterial injection once) effects systolic blood pressure in vivo^[1].
H-Tyr-Tyr-OH (0-100 mg/kg; i.p. once) effects blood pressure of spontaneously hypertensive rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Anesthetized male SpragueDawley rats^[1]
Dosage:	12.5 mg/kg
Administration:	Intraarterial injection; 12.5 mg/kg once
Result:	Significantly elevated systolic blood pressure, with a peak increase of 5 min after administration.

Animal Model:	Spontaneously hypertensive rats^[1]
Dosage:	0, 50 and 100 mg/kg
Administration:	Intraperitoneal injection; once
Result:	Significantly reduced blood pressure of spontaneously hypertensive rats, even at a dose of 50 mg/kg.

Molecular Weight

344.36

Formula

C₁₈H₂₀N₂O₅

CAS No.

1050-28-8

Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=C(C[C@H](NC([C@@H](N)CC2=CC=C(C=C2)O)=O)C(O)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (290.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (290.39 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9039 mL	14.5197 mL	29.0394 mL
5 mM	0.5808 mL	2.9039 mL	5.8079 mL
10 mM	0.2904 mL	1.4520 mL	2.9039 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.26 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.26 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (7.26 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (246 KB)

Handling Instructions (2659 KB)

References

[1]. Maher TJ, et al. Use of parenteral dipeptides to increase serum tyrosine levels and to enhance catecholamine-mediated neurotransmission. J Pharm Sci. 1990 Aug;79(8):685-7. [Content Brief]

[2]. Maruyama, et al. Purification and identification of angiotensin I-converting enzyme inhibitory peptides from Royal Jelly treated with protease. Nippon Shokuhin Kagaku Kogaku Kaishi. 2003.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.9039 mL	14.5197 mL	29.0394 mL	72.5984 mL
	5 mM	0.5808 mL	2.9039 mL	5.8079 mL	14.5197 mL
	10 mM	0.2904 mL	1.4520 mL	2.9039 mL	7.2598 mL
	15 mM	0.1936 mL	0.9680 mL	1.9360 mL	4.8399 mL
	20 mM	0.1452 mL	0.7260 mL	1.4520 mL	3.6299 mL
	25 mM	0.1162 mL	0.5808 mL	1.1616 mL	2.9039 mL
	30 mM	0.0968 mL	0.4840 mL	0.9680 mL	2.4199 mL
	40 mM	0.0726 mL	0.3630 mL	0.7260 mL	1.8150 mL
	50 mM	0.0581 mL	0.2904 mL	0.5808 mL	1.4520 mL
	60 mM	0.0484 mL	0.2420 mL	0.4840 mL	1.2100 mL
	80 mM	0.0363 mL	0.1815 mL	0.3630 mL	0.9075 mL
	100 mM	0.0290 mL	0.1452 mL	0.2904 mL	0.7260 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

H-Tyr-Tyr-OH Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

H-Tyr-Tyr-OH1050-28-8L-Tyrosyl-L-tyrosineAngiotensin-converting Enzyme (ACE)antihypertensive peptidehigh blood pressuresystolic blood pressurespontaneously hypertensive ratInhibitorinhibitorinhibit

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H-Tyr-Tyr-OH (Synonyms: L-Tyrosyl-L-tyrosine)

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H-Tyr-Tyr-OH Related Antibodies

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Biological Activity

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Complete Stock Solution Preparation Table

H-Tyr-Tyr-OH Related Classifications

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