2. Cell Cycle/DNA Damage
  3. PERK
  4. HC-5404-Fu

HC-5404-Fu is a PERK inhibitor with an antitumor activity. HC-5404-Fu inhibits endoplasmic reticulum stress response signalling. HC-5404-Fu sensitizes renal cell carcinoma cells to vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitors (TKIs). HC-5404-Fu is promising for research of renal cell carcinoma, gastric cancer, metastatic breast cancer, small cell lung cancer, and other solid tumors.

For research use only. We do not sell to patients.

HC-5404-Fu Chemical Structure

HC-5404-Fu Chemical Structure

CAS No. : 3034479-99-4

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HC-5404-Fu Related Antibodies

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Description

HC-5404-Fu is a PERK inhibitor with an antitumor activity. HC-5404-Fu inhibits endoplasmic reticulum stress response signalling. HC-5404-Fu sensitizes renal cell carcinoma cells to vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitors (TKIs). HC-5404-Fu is promising for research of renal cell carcinoma, gastric cancer, metastatic breast cancer, small cell lung cancer, and other solid tumors[1][2][3].

Molecular Weight

512.51

Formula

C24H24F2N4O3.1/2C4H4O4
CAS No.
SMILES

CC(C)NC(C1=CC(C2=CC=C(C=C2C)NC([C@@H](C3=CC(F)=CC(F)=C3)O)=O)=CN=C1N)=O.O=C(O)/C=C/C(O)=O.[1/2]
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HC-5404-Fu Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HC-5404-Fu3034479-99-4PERKProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseantitumor activityendoplasmic reticulum stress response signallingVEGF receptorTKIssolid tumorsInhibitorinhibitorinhibit

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