HDAC-IN-72

Cat. No.: HY-162487: FAQs
Data Sheet Handling Instructions

Molarity Calculator

HDAC-IN-72 (compound 7j) is the most potent HDAC1 (IC₅₀=0.65 μM), HDAC2 (IC₅₀=0.78 μM), HDAC3 (IC₅₀=1.70 μM) inhibitor and antiproliferative compound. HDAC-IN-72 can be used for breast cancer research.

For research use only. We do not sell to patients.

HDAC-IN-72 Chemical Structure

CAS No. : 763066-77-9

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•Related Small Molecules:

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View All Isoforms

HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

HDAC1

0.65 μM (IC₅₀)

HDAC2

0.78 μM (IC₅₀)

HDAC3

1.70 μM (IC₅₀)

In Vitro

HDAC-IN-72 (0.1-50 μM, 48 h) shows good anti-proliferative activity against MCF-7 (IC₅₀=0.83±1.41 μM) and T47D (IC₅₀=1.4±1.85 μM) cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

359.42

Formula

C₂₂H₂₁N₃O₂

CAS No.

763066-77-9

SMILES

O=C(NCC1=CC=C(C(NC2=CC=CC=C2N)=O)C=C1)C3=CC=C(C)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cheshmazar N, et al. Key structural requirements of benzamide derivatives for histone deacetylase inhibition: design, synthesis and biological evaluation[J]. Future Medicinal Chemistry, 2024 (0). [Content Brief]

HDAC-IN-72 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-72763066-77-9HDACHistone deacetylasesHistone deacetylase inhibitorsbenzamide-based derivativesHDAC inhibitorInhibitorinhibitorinhibit

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