2. PROTAC Cell Cycle/DNA Damage Epigenetics
  3. Ligands for Target Protein for PROTAC HDAC
  4. HDAC6 ligand-2

HDAC6 ligand-2 (Compound 15) is the ligand for HDAC6 that can be used for synthesis of PROTAC HDAC6 degrader 2 (HY-171139).

For research use only. We do not sell to patients.

HDAC6 ligand-2 Chemical Structure

HDAC6 ligand-2 Chemical Structure

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Based on 1 publication(s) in Google Scholar

HDAC6 ligand-2 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

HDAC6 ligand-2 (Compound 15) is the ligand for HDAC6 that can be used for synthesis of PROTAC HDAC6 degrader 2 (HY-171139)[1].

Molecular Weight

466.44

Formula

C23H20F2N6O3
Appearance

Solid

Color

White to off-white

SMILES

FC(C1=NN=C(C2=CN=C(NCC3=CC(CNC(OCC4=CC=CC=C4)=O)=CC=C3)N=C2)O1)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (214.39 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1439 mL 10.7195 mL 21.4390 mL
5 mM 0.4288 mL 2.1439 mL 4.2878 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1439 mL 10.7195 mL 21.4390 mL 53.5975 mL
5 mM 0.4288 mL 2.1439 mL 4.2878 mL 10.7195 mL
10 mM 0.2144 mL 1.0719 mL 2.1439 mL 5.3597 mL
15 mM 0.1429 mL 0.7146 mL 1.4293 mL 3.5732 mL
20 mM 0.1072 mL 0.5360 mL 1.0719 mL 2.6799 mL
25 mM 0.0858 mL 0.4288 mL 0.8576 mL 2.1439 mL
30 mM 0.0715 mL 0.3573 mL 0.7146 mL 1.7866 mL
40 mM 0.0536 mL 0.2680 mL 0.5360 mL 1.3399 mL
50 mM 0.0429 mL 0.2144 mL 0.4288 mL 1.0719 mL
60 mM 0.0357 mL 0.1787 mL 0.3573 mL 0.8933 mL
80 mM 0.0268 mL 0.1340 mL 0.2680 mL 0.6700 mL
100 mM 0.0214 mL 0.1072 mL 0.2144 mL 0.5360 mL
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HDAC6 ligand-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6 ligand-2Ligands for Target Protein for PROTACHDACTarget Protein-binding MoietyHistone deacetylasesInhibitorinhibitorinhibit

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