2. Metabolic Enzyme/Protease
  3. Dihydroorotate Dehydrogenase
  4. hDHODH-IN-13

hDHODH-IN-13 (compound w2) is an inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC50 value of 173.4 nM. hDHODH-IN-13 can be used in the research of IBD.

For research use only. We do not sell to patients.

hDHODH-IN-13 Chemical Structure

hDHODH-IN-13 Chemical Structure

CAS No. : 3032611-13-2

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5 mg USD 165 In-stock
10 mg USD 260 In-stock
25 mg USD 516 In-stock
50 mg USD 825 In-stock
100 mg USD 1320 In-stock
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Based on 1 publication(s) in Google Scholar

hDHODH-IN-13 Related Antibodies

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Description

hDHODH-IN-13 (compound w2) is an inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC50 value of 173.4 nM. hDHODH-IN-13 can be used in the research of IBD[1].

Molecular Weight

393.84

Formula

C21H17ClFN5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=NC(C2=CN(CC3=C(F)C=CC=C3Cl)C4=NC=CC=C42)=NC=C1C5CC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (317.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5391 mL 12.6955 mL 25.3910 mL
5 mM 0.5078 mL 2.5391 mL 5.0782 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5391 mL 12.6955 mL 25.3910 mL 63.4776 mL
5 mM 0.5078 mL 2.5391 mL 5.0782 mL 12.6955 mL
10 mM 0.2539 mL 1.2696 mL 2.5391 mL 6.3478 mL
15 mM 0.1693 mL 0.8464 mL 1.6927 mL 4.2318 mL
20 mM 0.1270 mL 0.6348 mL 1.2696 mL 3.1739 mL
25 mM 0.1016 mL 0.5078 mL 1.0156 mL 2.5391 mL
30 mM 0.0846 mL 0.4232 mL 0.8464 mL 2.1159 mL
40 mM 0.0635 mL 0.3174 mL 0.6348 mL 1.5869 mL
50 mM 0.0508 mL 0.2539 mL 0.5078 mL 1.2696 mL
60 mM 0.0423 mL 0.2116 mL 0.4232 mL 1.0580 mL
80 mM 0.0317 mL 0.1587 mL 0.3174 mL 0.7935 mL
100 mM 0.0254 mL 0.1270 mL 0.2539 mL 0.6348 mL
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hDHODH-IN-13 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hDHODH-IN-133032611-13-2Dihydroorotate DehydrogenaseDHODHhDHODH InhibitorInhibitorinhibitorinhibit

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