2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Hippeastrine hydrobromide

Hippeastrine hydrobromide is an active alkaloid that exhibits a good dose-dependent inhibitory effect on topoisomerase I (Top I) with an IC50 of 7.25?μg/mL. Hippeastrine hydrobromide exhibits antiproliferative and anticancer activities.

For research use only. We do not sell to patients.

Hippeastrine hydrobromide Chemical Structure

Hippeastrine hydrobromide Chemical Structure

CAS No. : 22352-41-6

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of Hippeastrine hydrobromide:

Hippeastrine hydrobromide Related Antibodies

Top Publications Citing Use of Products

View All Topoisomerase Isoform Specific Products:

View All Isoforms
Topoisomerase Topo I Topo II

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Hippeastrine hydrobromide is an active alkaloid that exhibits a good dose-dependent inhibitory effect on topoisomerase I (Top I) with an IC50 of 7.25?μg/mL. Hippeastrine hydrobromide exhibits antiproliferative and anticancer activities[1].

Cellular Effect
Cell Line Type Value Description References
A-431 ED50
6.3 μg/mL
Compound: (+)-Hippeastrine
Cytotoxicity against human A431 cells after 3 days by sulforhodamine B assay
Cytotoxicity against human A431 cells after 3 days by sulforhodamine B assay
[PMID: 8229020]
BC1 cell line ED50
> 20 μg/mL
Compound: (+)-Hippeastrine
Cytotoxicity against human BC1 cells after 3 days by sulforhodamine B assay
Cytotoxicity against human BC1 cells after 3 days by sulforhodamine B assay
[PMID: 8229020]
Col2 ED50
7.8 μg/mL
Compound: (+)-Hippeastrine
Cytotoxicity against human Col2 cells after 3 days by sulforhodamine B assay
Cytotoxicity against human Col2 cells after 3 days by sulforhodamine B assay
[PMID: 8229020]
HT ED50
4.7 μg/mL
Compound: (+)-Hippeastrine
Cytotoxicity against human HT cells after 3 days by sulforhodamine B assay
Cytotoxicity against human HT cells after 3 days by sulforhodamine B assay
[PMID: 8229020]
KB ED50
> 20 μg/mL
Compound: (+)-Hippeastrine
Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay
Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay
[PMID: 8229020]
KB-V1 ED50
> 20 μg/mL
Compound: (+)-Hippeastrine
Cytotoxicity against human KBV1 cells after 3 days by sulforhodamine B assay
Cytotoxicity against human KBV1 cells after 3 days by sulforhodamine B assay
[PMID: 8229020]
LNCaP ED50
1.8 μg/mL
Compound: (+)-Hippeastrine
Cytotoxicity against human LNCAP cells after 3 days by sulforhodamine B assay
Cytotoxicity against human LNCAP cells after 3 days by sulforhodamine B assay
[PMID: 8229020]
Lu1 ED50
5.2 μg/mL
Compound: (+)-Hippeastrine
Cytotoxicity against human Lu1 cells after 3 days by sulforhodamine B assay
Cytotoxicity against human Lu1 cells after 3 days by sulforhodamine B assay
[PMID: 8229020]
P388 ED50
4 μg/mL
Compound: (+)-Hippeastrine
Cytotoxicity against mouse P388 cells after 3 days by sulforhodamine B assay
Cytotoxicity against mouse P388 cells after 3 days by sulforhodamine B assay
[PMID: 8229020]
SK-MEL-2 ED50
> 20 μg/mL
Compound: (+)-Hippeastrine
Cytotoxicity against human SK-MEL-2 cells after 3 days by sulforhodamine B assay
Cytotoxicity against human SK-MEL-2 cells after 3 days by sulforhodamine B assay
[PMID: 8229020]
ZR-75-1 ED50
7.3 μg/mL
Compound: (+)-Hippeastrine
Cytotoxicity against human ZR-75-1 cells after 3 days by sulforhodamine B assay
Cytotoxicity against human ZR-75-1 cells after 3 days by sulforhodamine B assay
[PMID: 8229020]
Molecular Weight

396.23

Formula

C17H18BrNO5
CAS No.
SMILES

O=C1O[C@]([H])([C@H](C=C2CCN(C32)C)O)[C@@]3([H])C4=CC5=C(OCO5)C=C14.Br
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Hippeastrine hydrobromide Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hippeastrine22352-41-6TopoisomeraseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Hippeastrine hydrobromide
Cat. No.:
HY-N6621A
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (0 KB) Français - FR (0 KB) Deutsch - DE (0 KB) Norwegian - NO (0 KB) Español - ES (0 KB) Swedish - SV (0 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.