1. Cell Cycle/DNA Damage
  2. Topoisomerase
  3. Hippeastrine

Hippeastrine, an active alkaloid, exhibits a good dose-dependent inhibitory effect against topoisomerase I (Top I) with an IC50 at 7.25 μg/mL. Antiproliferative and anticancer activities.

For research use only. We do not sell to patients.

Hippeastrine Chemical Structure

Hippeastrine Chemical Structure

CAS No. : 477-17-8

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Description

Hippeastrine, an active alkaloid, exhibits a good dose-dependent inhibitory effect against topoisomerase I (Top I) with an IC50 at 7.25 μg/mL. Antiproliferative and anticancer activities[1].

In Vitro

Hippeastrine strongly inhibits the proliferation of HT-29 and Hep G2 cells in an intuitive dose-dependent manner with the IC50s at 3.98 μg/mL and 11.85 μg/mL, respectively, and also induces significant cellular morphological changes, which further validate our screening method and the potent antineoplastic effects[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

315.32

Formula

C17H17NO5

CAS No.
SMILES

O=C1O[C@]([H])([C@H](C=C2CCN(C32)C)O)[C@@]3([H])C4=CC5=C(OCO5)C=C14

Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Hippeastrine
Cat. No.:
HY-N6621
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