IACS-8803 disodium

Name: IACS-8803 disodium
Brand: MedChemExpress
SKU: HY-130115A
Rating: 4.5 (1 reviews)

Cat. No.: HY-130115A Purity: 98.79%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

IACS-8803 disodium is a highly potent cyclic dinucleotide STING agonist. IACS-8803 disodium has a robust systemic antitumor efficacy.

For research use only. We do not sell to patients.

IACS-8803 disodium Chemical Structure

CAS No. : 2243079-36-7

Size	Price	Stock	Quantity
1 mg	USD 600	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1500	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 2400	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 4800	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 7800	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of IACS-8803 disodium:

IACS-8803 Get quote
IACS-8803 diammonium Get quote

1 Publications Citing Use of MCE IACS-8803 disodium

•Clin Cancer Res. 2024 Sep 13;30(18):4190-4200. [Abstract]

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IACS-8803 disodium is a highly potent cyclic dinucleotide STING agonist. IACS-8803 disodium has a robust systemic antitumor efficacy^[1].

In Vivo

IACS-8803 (10 μg; intra-tumoral injection) shows superior antitumor activity in mice bearing bilateral B16-OVA melanomas^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

736.50

Formula

C₂₀H₂₁FN₁₀Na₂O₉P₂S₂

CAS No.

2243079-36-7

Appearance

Solid

Color

White to off-white

SMILES

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](F)[C@H](O[P@@]4(S[Na])=O)[C@@H](CO[P@](O[C@@H]5[C@H](O)[C@@H](CO4)O[C@H]5N(C=N6)C7=C6C(N)=NC=N7)(S[Na])=O)O3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (135.78 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 56.67 mg/mL (76.95 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3578 mL	6.7889 mL	13.5777 mL
5 mM	0.2716 mL	1.3578 mL	2.7155 mL
10 mM	0.1358 mL	0.6789 mL	1.3578 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.39 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (3.39 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (3.39 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (67.89 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.97%

Select Batch:

Data Sheet (279 KB) SDS (252 KB)

COA (257 KB) HNMR (260 KB) CNMR (346 KB) LCMS (140 KB)

Handling Instructions (2659 KB)

References

[1]. Ager CR, et al. Discovery of IACS-8803 and IACS-8779, potent agonists of stimulator of interferon genes (STING) with robust systemic antitumor efficacy. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126640. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.3578 mL	6.7889 mL	13.5777 mL	33.9443 mL
	5 mM	0.2716 mL	1.3578 mL	2.7155 mL	6.7889 mL
	10 mM	0.1358 mL	0.6789 mL	1.3578 mL	3.3944 mL
	15 mM	0.0905 mL	0.4526 mL	0.9052 mL	2.2630 mL
	20 mM	0.0679 mL	0.3394 mL	0.6789 mL	1.6972 mL
	25 mM	0.0543 mL	0.2716 mL	0.5431 mL	1.3578 mL
	30 mM	0.0453 mL	0.2263 mL	0.4526 mL	1.1315 mL
	40 mM	0.0339 mL	0.1697 mL	0.3394 mL	0.8486 mL
	50 mM	0.0272 mL	0.1358 mL	0.2716 mL	0.6789 mL
	60 mM	0.0226 mL	0.1131 mL	0.2263 mL	0.5657 mL
DMSO	80 mM	0.0170 mL	0.0849 mL	0.1697 mL	0.4243 mL
DMSO	100 mM	0.0136 mL	0.0679 mL	0.1358 mL	0.3394 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.