IBG3

Cat. No.: HY-160528 Purity: 98.53%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

IBG3 is a dual-JQ1-containing BET molecular glue degrader that targets protein degradation via intramolecular bivalent glues. IBG3 is a BRD2 and BRD4 bifunctional degrader with DC₅₀ values of 8.6 pM and 6.7 pM, respectively.

For research use only. We do not sell to patients.

IBG3 Chemical Structure

Size		Stock
5 mg		Check price and availability
10 mg		Check price and availability
25 mg		Check price and availability
50 mg		Check price and availability

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

BRD2

8.6 pM (DC₅₀)

BRD4

6.7 pM (DC₅₀)

Molecular Weight

976.22

Formula

C₅₄H₅₇N₉O₅S₂

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NCC1=CC=C(C2=N[C@@H](CC(OC(C)(C)C)=O)C3=NN=C(C)N3C4=C2C(C)=C(C)S4)C=C1)C5=CC=C(C6=CC=C(C7=N[C@@H](CC(OC(C)(C)C)=O)C8=NN=C(C)N8C9=C7C(C)=C(C)S9)C=C6)C=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (102.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0244 mL	5.1218 mL	10.2436 mL
5 mM	0.2049 mL	1.0244 mL	2.0487 mL
10 mM	0.1024 mL	0.5122 mL	1.0244 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.53%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (256 KB) HNMR (148 KB) RP-HPLC (171 KB) LCMS (235 KB)

Handling Instructions (2659 KB)

References

[1]. Oliver Hsia, et al. Targeted protein degradation via intramolecular bivalent glues. Nature. 2024 Feb 21. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0244 mL	5.1218 mL	10.2436 mL	25.6090 mL
	5 mM	0.2049 mL	1.0244 mL	2.0487 mL	5.1218 mL
	10 mM	0.1024 mL	0.5122 mL	1.0244 mL	2.5609 mL
	15 mM	0.0683 mL	0.3415 mL	0.6829 mL	1.7073 mL
	20 mM	0.0512 mL	0.2561 mL	0.5122 mL	1.2804 mL
	25 mM	0.0410 mL	0.2049 mL	0.4097 mL	1.0244 mL
	30 mM	0.0341 mL	0.1707 mL	0.3415 mL	0.8536 mL
	40 mM	0.0256 mL	0.1280 mL	0.2561 mL	0.6402 mL
	50 mM	0.0205 mL	0.1024 mL	0.2049 mL	0.5122 mL
	60 mM	0.0171 mL	0.0854 mL	0.1707 mL	0.4268 mL
	80 mM	0.0128 mL	0.0640 mL	0.1280 mL	0.3201 mL
	100 mM	0.0102 mL	0.0512 mL	0.1024 mL	0.2561 mL

IBG3 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IBG3IBG 3IBG-3Molecular GluesEpigenetic Reader DomainBRD2BRD4 degraderintramolecular bivalent gluesJQ1DCAF16Inhibitorinhibitorinhibit

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