ICI-63197 

ICI-63197 is a phosphodiesterase 3 (PDE3) and PDE4 inhibitor with K_i values of 9 µM and 10 µM, respectively. ICI-63197 is selectivity against PDE1 and PDE2. ICI-63197 has antidepressant effects^[1][2].

In rabbit isolated pulmonary artery previously incubated with [³H]-noradrenaline, ICI-63197 (30 μM) significantly enhances the stimulation-induced outflow of radioactivity^[3].
At a stimulation frequency of 2 Hz in mouse atria, ICI-63197 (30 μM) shows no effect on the stimulation-induced outflow^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thirty and ninety minutes after intraperitoneal administration, ICI 63197, 0.48-29.9 µmol/kg, dose-dependently antagonized the Reserpine induced hypothermia in mice^[2].
ICI-63197 potentiates the locomotor stimulatory effect of dopamine or of the ergot dopamine agonist Lisuride administered directly into the nucleus accumbens of rats. ICI-63197 has property of enhancing central noradrenergic transmission^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

207.23

C₉H₁₃N₅O

27277-00-5

O=C1N(CCC)C2=NC(N)=NN2C=C1C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. M Hoey, et al. Identification and selective inhibition of four distinct soluble forms of cyclic nucleotide phosphodiesterase activity from kidney. Biochem Pharmacol. 1990 Jul 15;40(2):193-202.  [Content Brief]

  [2]. H Wachtel. Potential antidepressant activity of rolipram and other selective cyclic adenosine 3',5'-monophosphate phosphodiesterase inhibitors. Neuropharmacology. 1983 Mar;22(3):267-72.  [Content Brief]

  [3]. H Johnston, et al. Prejunctional beta-adrenoceptors in rabbit pulmonary artery and mouse atria: effect of alpha-adrenoceptor blockade and phosphodiesterase inhibition. Br J Pharmacol. 1986 Mar;87(3):553-62.  [Content Brief]