2. Immunology/Inflammation Stem Cell/Wnt JAK/STAT Signaling
  3. Interleukin Related STAT
  4. Icotrokinra

Icotrokinra  (Synonyms: JNJ-77242113; JNJ-2113; PN-235)

Cat. No.: HY-P10587 Purity: 99.89%
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Icotrokinra (JNJ-77242113) is a selective, orally active antagonist for IL-23 receptor. Icotrokinra exhibits high affinity with human IL-23 receptor hIL-23R with a Kd of 7.1 pM. Icotrokinra inhibits IL-23-induced STAT3 phosphorylation in PMBCs (IC50=5.6 pM), and inhibits L-23-induced generation of IFNγ and IL-17A in picomolar levels. Icotrokinra exhibits anti-inflammatory activity in rat TNBS-induced colitis model.

For research use only. We do not sell to patients.

Icotrokinra Chemical Structure

Icotrokinra Chemical Structure

CAS No. : 2763602-16-8

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1 mg USD 280 In-stock
5 mg USD 680 In-stock
10 mg USD 980 In-stock
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Based on 1 publication(s) in Google Scholar

Icotrokinra Related Antibodies

Top Publications Citing Use of Products

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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STAT3 STAT5 STAT6 STAT1

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Description

Icotrokinra (JNJ-77242113) is a selective, orally active antagonist for IL-23 receptor. Icotrokinra exhibits high affinity with human IL-23 receptor hIL-23R with a Kd of 7.1 pM. Icotrokinra inhibits IL-23-induced STAT3 phosphorylation in PMBCs (IC50=5.6 pM), and inhibits L-23-induced generation of IFNγ and IL-17A in picomolar levels. Icotrokinra exhibits anti-inflammatory activity in rat TNBS-induced colitis model[1].

IC50 & Target

IL-23

7.1 pM (Kd)

Molecular Weight

1898.17

Formula

C90H120N20O22S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ac-Pen-Asn-Thr-Trp(7-Me)-Lys(Ac)-Pen-Phe(4-amino ethoxy)-2Nal-ThpGly-Glu-Asn-3Pal-Sar-NH2 (Pen1&Pen6 bridge)
SMILES

NCCOC(C=C1)=CC=C1C[C@H](NC([C@H]2NC([C@@H](NC([C@@H](NC([C@](NC([C@@H](NC([C@H](C(C)(SSC2(C)C)C)NC(C)=O)=O)CC(N)=O)=O)([H])[C@H](O)C)=O)CC(C3=CC=C4)=CNC3=C4C)=O)CCCCNC(C)=O)=O)=O)C(N[C@@H](CC5=CC6=C(C=CC=C6)C=C5)C(NC7(CCOCC7)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@H](C(N(C)CC(N)=O)=O)CC8=CN=CC=C8)=O)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (52.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5268 mL 2.6341 mL 5.2682 mL
5 mM 0.1054 mL 0.5268 mL 1.0536 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5268 mL 2.6341 mL 5.2682 mL 13.1706 mL
5 mM 0.1054 mL 0.5268 mL 1.0536 mL 2.6341 mL
10 mM 0.0527 mL 0.2634 mL 0.5268 mL 1.3171 mL
15 mM 0.0351 mL 0.1756 mL 0.3512 mL 0.8780 mL
20 mM 0.0263 mL 0.1317 mL 0.2634 mL 0.6585 mL
25 mM 0.0211 mL 0.1054 mL 0.2107 mL 0.5268 mL
30 mM 0.0176 mL 0.0878 mL 0.1756 mL 0.4390 mL
40 mM 0.0132 mL 0.0659 mL 0.1317 mL 0.3293 mL
50 mM 0.0105 mL 0.0527 mL 0.1054 mL 0.2634 mL
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Icotrokinra Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Icotrokinra2763602-16-8JNJ-77242113 JNJ-2113 PN-235JNJ77242113JNJ 77242113JNJ2113JNJ 2113JNJ-2113PN235PN 235PN-235Interleukin RelatedSTATILPMBCpsoriasiscolitisSprague-Dawley ratinflammatory bowel diseaseorally activeInhibitorinhibitorinhibit

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