2. Anti-infection Metabolic Enzyme/Protease
  3. HCV HCV Protease
  4. IDX184

IDX184 is a potent and orally bioavailable inhibitor of HCV replication. IDX184 potently inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3 nM).

For research use only. We do not sell to patients.

IDX184 Chemical Structure

IDX184 Chemical Structure

CAS No. : 1036915-08-8

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1 mg USD 328 In-stock
5 mg USD 820 In-stock
10 mg USD 1320 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

IDX184 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

IDX184 is a potent and orally bioavailable inhibitor of HCV replication. IDX184 potently inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3 nM)[1][2].

IC50 & Target

IC50: 0.31 μM (HCV polymerase)[2]
Ki: 52.3 nM (HCV polymerase)[2]
Cellular Effect
Cell Line Type Value Description References
CCRF-CEM CC50
> 100 μM
Compound: 2; IDX-184
Cytotoxicity against human CEM cells after 6 days by trypan blue exclusion assay
Cytotoxicity against human CEM cells after 6 days by trypan blue exclusion assay
[PMID: 26819659]
Huh-7 CC50
> 100 μM
Compound: 2; IDX-184
Cytotoxicity against human HuH7 cells infected with HCV assessed as reduction in cellular rRNA level after 96 hrs by qRT-PCR analysis
Cytotoxicity against human HuH7 cells infected with HCV assessed as reduction in cellular rRNA level after 96 hrs by qRT-PCR analysis
[PMID: 26819659]
PBMC CC50
> 100 μM
Compound: 2; IDX-184
Cytotoxicity against human PBMC after 6 days by trypan blue exclusion assay
Cytotoxicity against human PBMC after 6 days by trypan blue exclusion assay
[PMID: 26819659]
Vero CC50
> 100 μM
Compound: 2; IDX-184
Cytotoxicity against African green monkey Vero cells after 3 days by hemocytometry
Cytotoxicity against African green monkey Vero cells after 3 days by hemocytometry
[PMID: 26819659]
In Vitro

IDX184 is a liver-targeted prodrug of the nucleotide 2′-MeG-MP. IDX184 is a liver-targeted nucleotide polymerase inhibitor of hepatitis C virus[1].
IDX184 is a second generation, orally bioavailable nucleotide prodrug designed to provide increased anti-HCV efficacy and safety versus the parent nucleoside. In HCV replicon testing, IDX184 is the most potent inhibitor (EC50=0.3-0.45 μM) compared to any of the 2’ or 4’ modified nucleosides (EC50=4-6 μM) and is also highly inhibitory in the JFH-1 infectious system (EC50=0.06-0.11 μM). IDX184 is not toxic (CC50>100μM) in any tested cell line[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IDX184 Related Antibodies
Clinical Trial
Molecular Weight

626.62

Formula

C25H35N6O9PS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@]([C@](O[C@@H]1CO[P](NCC2=CC=CC=C2)(OCCSC(C(C)(C)CO)=O)=O)([H])N3C(NC(N)=NC4=O)=C4N=C3)([C@@H]1O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (398.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5959 mL 7.9793 mL 15.9586 mL
5 mM 0.3192 mL 1.5959 mL 3.1917 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

V1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5959 mL 7.9793 mL 15.9586 mL 39.8966 mL
5 mM 0.3192 mL 1.5959 mL 3.1917 mL 7.9793 mL
10 mM 0.1596 mL 0.7979 mL 1.5959 mL 3.9897 mL
15 mM 0.1064 mL 0.5320 mL 1.0639 mL 2.6598 mL
20 mM 0.0798 mL 0.3990 mL 0.7979 mL 1.9948 mL
25 mM 0.0638 mL 0.3192 mL 0.6383 mL 1.5959 mL
30 mM 0.0532 mL 0.2660 mL 0.5320 mL 1.3299 mL
40 mM 0.0399 mL 0.1995 mL 0.3990 mL 0.9974 mL
50 mM 0.0319 mL 0.1596 mL 0.3192 mL 0.7979 mL
60 mM 0.0266 mL 0.1330 mL 0.2660 mL 0.6649 mL
80 mM 0.0199 mL 0.0997 mL 0.1995 mL 0.4987 mL
100 mM 0.0160 mL 0.0798 mL 0.1596 mL 0.3990 mL
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IDX184 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDX1841036915-08-8IDX 184IDX-184HCVHCV ProteaseHepatitis C virusreplicationJFH-1infectiousInhibitorinhibitorinhibit

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