2. Protein Tyrosine Kinase/RTK
  3. Insulin Receptor
  4. IGF2BP1-IN-1

IGF2BP1-IN-1 (Compound A11) is a IGF2BP1 inhibitor and inhibits downstream signaling. IGF2BP1-IN-1 binds to IGF2BP1 protein with a KD value of 2.88 nM. IGF2BP1-IN-1 inhibits cancer cells proliferation (IC50: 9 nM for A549 cell, 34 nM for HCT116). IGF2BP1-IN-1 induces cancer cell apoptosis. GF2BP1-IN-1 inhibits tumor growth in A549 xenograft mouse model.

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IGF2BP1-IN-1 Chemical Structure

IGF2BP1-IN-1 Chemical Structure

CAS No. : 3029447-08-0

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1 mg USD 148 In-stock
5 mg USD 370 In-stock
10 mg USD 600 In-stock
25 mg USD 1200 In-stock
50 mg USD 1920 In-stock
100 mg USD 3080 In-stock
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Based on 1 publication(s) in Google Scholar

IGF2BP1-IN-1 Related Antibodies

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Description

IGF2BP1-IN-1 (Compound A11) is a IGF2BP1 inhibitor and inhibits downstream signaling. IGF2BP1-IN-1 binds to IGF2BP1 protein with a KD value of 2.88 nM. IGF2BP1-IN-1 inhibits cancer cells proliferation (IC50: 9 nM for A549 cell, 34 nM for HCT116). IGF2BP1-IN-1 induces cancer cell apoptosis. GF2BP1-IN-1 inhibits tumor growth in A549 xenograft mouse model[1].

IC50 & Target

KD: 2.88 nM (IGF2BP1)[1]
Molecular Weight

777.87

Formula

C42H52FN3O10
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@@]3([H])[C@]([C@@]4([H])C(C(C)(C([C@H](C4)OC(CN5C(N(C6=CC=C(C=C6)F)C=N5)=O)=O)=O)C)=CC3)(C(C[C@@]1([C@@]([C@@H](C2)O)([H])[C@@](C)(O)C(/C=C/C(C)(C)OC(C)=O)=O)C)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (128.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2856 mL 6.4278 mL 12.8556 mL
5 mM 0.2571 mL 1.2856 mL 2.5711 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2856 mL 6.4278 mL 12.8556 mL 32.1390 mL
5 mM 0.2571 mL 1.2856 mL 2.5711 mL 6.4278 mL
10 mM 0.1286 mL 0.6428 mL 1.2856 mL 3.2139 mL
15 mM 0.0857 mL 0.4285 mL 0.8570 mL 2.1426 mL
20 mM 0.0643 mL 0.3214 mL 0.6428 mL 1.6070 mL
25 mM 0.0514 mL 0.2571 mL 0.5142 mL 1.2856 mL
30 mM 0.0429 mL 0.2143 mL 0.4285 mL 1.0713 mL
40 mM 0.0321 mL 0.1607 mL 0.3214 mL 0.8035 mL
50 mM 0.0257 mL 0.1286 mL 0.2571 mL 0.6428 mL
60 mM 0.0214 mL 0.1071 mL 0.2143 mL 0.5357 mL
80 mM 0.0161 mL 0.0803 mL 0.1607 mL 0.4017 mL
100 mM 0.0129 mL 0.0643 mL 0.1286 mL 0.3214 mL
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IGF2BP1-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IGF2BP1-IN-13029447-08-0Insulin ReceptorcancertumorCucurbitacin BA549HCT116A549 xenograft， NSCLCInhibitorinhibitorinhibit

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