2. Metabolic Enzyme/Protease
  3. Aldehyde Dehydrogenase (ALDH)
  4. IGUANA-1 free base

IGUANA-1 free base  (Synonyms: STL5-T-0057)

Cat. No.: HY-148243 Purity: 99.69%
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IGUANA-1 free base (STL5-T-0057) is an selective ALDH1 B1 inhibitor with an IC50 value of 30 nM. IGUANA-1 free base inhibits cell growth of SW480 cells in adherent and spheroid conditions with IC50 values of 2.46 and 0.39 μM, respectively. IGUANA-1 free base can be used for the research of cancer.

For research use only. We do not sell to patients.

IGUANA-1 free base Chemical Structure

IGUANA-1 free base Chemical Structure

CAS No. : 2756014-24-9

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Based on 1 publication(s) in Google Scholar

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IGUANA-1 free base Related Antibodies

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Description

IGUANA-1 free base (STL5-T-0057) is an selective ALDH1 B1 inhibitor with an IC50 value of 30 nM. IGUANA-1 free base inhibits cell growth of SW480 cells in adherent and spheroid conditions with IC50 values of 2.46 and 0.39 μM, respectively. IGUANA-1 free base can be used for the research of cancer[1].

IC50 & Target

IC50: 30 nM (ALDH1 B1), 2.46 μM (SW480, adherent), 0.39 μM (SW480, spheroid)[1]
In Vitro

IGUANA-1 free base (compound 68) (0-10 μM) inhibits ALDH1 B1 with an IC50 value of 30 nM[1].
IGUANA-1 free base (0.01-10 μM; 4-5 d) inhibits cell growth of HEK293T cells[1].
IGUANA-1 free base (0.01-10 μM) inhibits cell viability of SW480 cells in adherent and spheroid conditions with IC50 values of 2.46 and 0.39 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IGUANA-1 free base Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HEK293T cell line
Concentration: 0.01-10 μM
Incubation Time: 4-5 d
Result: Showed cell cytotoxicity to HEK293T cells with a GI50 value of 1.7 μM.
Molecular Weight

445.94

Formula

C26H24ClN3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC1=CC(OC)=C(C2=CN(C3=NCCCN32)C4=CC=C(C5=C(OC)C=CC=C5)C=C4)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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IGUANA-1 free base Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IGUANA-12756014-24-9STL5-T-0057IGUANA1IGUANA 1Aldehyde Dehydrogenase (ALDH)selectiveSW480HEK293TcanceradherentspheroidInhibitorinhibitorinhibit

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