2. Immunology/Inflammation
  3. Interleukin Related
  4. IL-17A modulator-2

IL-17A modulator-2 is a IL-17A modulator, extracted from patent WO2021239743+A1, example 27. IL-17A modulator-2 inhibits the biological action of IL-17A with a pIC50 of 8.3. IL-17A modulator-2 can be used for the research of diseases or disorders associated with modulation of IL-17A activity including diseases with an immune component or autoimmune pathol, cancer and neurodegenerative disorders.

For research use only. We do not sell to patients.

IL-17A modulator-2 Chemical Structure

IL-17A modulator-2 Chemical Structure

CAS No. : 2748749-47-3

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5 mg USD 650 In-stock
10 mg USD 1050 In-stock
25 mg USD 2100 In-stock
50 mg USD 3380 In-stock
100 mg USD 5400 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of IL-17A modulator-2:

IL-17A modulator-2 Related Antibodies

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Description

IL-17A modulator-2 is a IL-17A modulator, extracted from patent WO2021239743+A1, example 27. IL-17A modulator-2 inhibits the biological action of IL-17A with a pIC50 of 8.3. IL-17A modulator-2 can be used for the research of diseases or disorders associated with modulation of IL-17A activity including diseases with an immune component or autoimmune pathol, cancer and neurodegenerative disorders[1].

IC50 & Target[1]

IL-17A

8.3 (pIC50)

Molecular Weight

577.63

Formula

C33H31N5O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=NN1C)N[C@H](C(NC2=CC=C(C3=C(OC)C=[N+]([O-])C=C3OC)C=C2)=O)C(C4=CC=CC=C4)C5=CC=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (173.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7312 mL 8.6561 mL 17.3121 mL
5 mM 0.3462 mL 1.7312 mL 3.4624 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7312 mL 8.6561 mL 17.3121 mL 43.2803 mL
5 mM 0.3462 mL 1.7312 mL 3.4624 mL 8.6561 mL
10 mM 0.1731 mL 0.8656 mL 1.7312 mL 4.3280 mL
15 mM 0.1154 mL 0.5771 mL 1.1541 mL 2.8854 mL
20 mM 0.0866 mL 0.4328 mL 0.8656 mL 2.1640 mL
25 mM 0.0692 mL 0.3462 mL 0.6925 mL 1.7312 mL
30 mM 0.0577 mL 0.2885 mL 0.5771 mL 1.4427 mL
40 mM 0.0433 mL 0.2164 mL 0.4328 mL 1.0820 mL
50 mM 0.0346 mL 0.1731 mL 0.3462 mL 0.8656 mL
60 mM 0.0289 mL 0.1443 mL 0.2885 mL 0.7213 mL
80 mM 0.0216 mL 0.1082 mL 0.2164 mL 0.5410 mL
100 mM 0.0173 mL 0.0866 mL 0.1731 mL 0.4328 mL
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IL-17A modulator-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IL-17A modulator-22748749-47-3Interleukin RelatedILmodulatorimmune componentcancerneurodegenerative disordersInhibitorinhibitorinhibit

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