Imazalil sulfate (Synonyms: Enilconazolel sulfate)

Cat. No.: HY-B1134A Purity: 99.63%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

Imazalil (Enilconazole) sulfate is a fungicide. Imazalil sulfate has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil sulfate is commonly used to protect various agricultural crops against fungal attack. Imazalil sulfate induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder.

For research use only. We do not sell to patients.

Imazalil sulfate Chemical Structure

CAS No. : 58594-72-2

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Imazalil sulfate:

Imazalil

Other Forms of Imazalil sulfate:

Imazalil In-stock
Imazalil-d₅ sulfate Get quote

1 Publications Citing Use of MCE Imazalil sulfate

•Anal Chem. 2019 May 7;91(9):6051-6056. [Abstract]

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Imazalil (Enilconazole; 3, 10, 30 μM; for 6 h) sulfate significantly suppressed IL-17 mRNAs^[1].
imazalil (1, 3, 10, 30, 100 μM; for 24 h) sulfate dose-dependently induces the reporter gene expression only in mPXR-expressed HepG2 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:	EL4 cells
Concentration:	3, 10, 30 μM
Incubation Time:	6 h
Result:	Significantly suppressed IL-17 mRNAs.

In Vivo

Imazalil (Enilconazole; 25-100 mg/kg; IP) sulfate significantly increases hepatic Cyp3a11 mRNA levels in a dose-dependent manner^[2].
Imazalil (75 mg/kg; ip; twice; once a day) sulfate combined with TCPOBOP (3 mg/kg) much greatly increased the number of Ki-67-positive nuclei and Mcm2 mRNA levels compared to its single treatment. Imazalil sulfate accelerates hepatocyte proliferation mediated by TCPOBOP treatment in mice^[2].
Imazalil (0.1, 0.5, or 2.5 mg/kg in drinking water for 15 weeks) sulfate induces oxidative stress and caused the disorders of bile acid metabolism in male adult C57BL/6 mice ^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	IMZ Male C57BL/6N mice^[2]
Dosage:	25, 50, 75, 100 mg/kg
Administration:	Intraperitoneally; single dose
Result:	Significantly increased hepatic Cyp3a11 mRNA levels in a dose-dependent manner.

Molecular Weight

395.26

Formula

C₁₄H₁₆Cl₂N₂O₅S

CAS No.

58594-72-2

Appearance

Solid

Color

White to off-white

SMILES

C=CCOC(C1=CC=C(Cl)C=C1Cl)CN2C=CN=C2.O=S(O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 116.67 mg/mL (295.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5300 mL	12.6499 mL	25.2998 mL
5 mM	0.5060 mL	2.5300 mL	5.0600 mL
10 mM	0.2530 mL	1.2650 mL	2.5300 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.63%

Select Batch:

Data Sheet (280 KB) SDS (863 KB)

COA (255 KB) HNMR (144 KB) LCMS (92 KB)

Handling Instructions (2659 KB)

References

[1]. Hiroyuki Kojima, et al. Inhibitory effects of azole-type fungicides on interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):338-45. [Content Brief]

[2]. Shohei Yoshimaru, et al. Acceleration of murine hepatocyte proliferation by imazalil through the activation of nuclear receptor PXR. J Toxicol Sci. 2018;43(7):443-450. [Content Brief]

[3]. Cuiyuan Jin, et al. Chronic exposure of mice to low doses of imazalil induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels. Environ Toxicol. 2018 Jun;33(6):650-658. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5300 mL	12.6499 mL	25.2998 mL	63.2495 mL
	5 mM	0.5060 mL	2.5300 mL	5.0600 mL	12.6499 mL
	10 mM	0.2530 mL	1.2650 mL	2.5300 mL	6.3250 mL
	15 mM	0.1687 mL	0.8433 mL	1.6867 mL	4.2166 mL
	20 mM	0.1265 mL	0.6325 mL	1.2650 mL	3.1625 mL
	25 mM	0.1012 mL	0.5060 mL	1.0120 mL	2.5300 mL
	30 mM	0.0843 mL	0.4217 mL	0.8433 mL	2.1083 mL
	40 mM	0.0632 mL	0.3162 mL	0.6325 mL	1.5812 mL
	50 mM	0.0506 mL	0.2530 mL	0.5060 mL	1.2650 mL
	60 mM	0.0422 mL	0.2108 mL	0.4217 mL	1.0542 mL
	80 mM	0.0316 mL	0.1581 mL	0.3162 mL	0.7906 mL
	100 mM	0.0253 mL	0.1265 mL	0.2530 mL	0.6325 mL

Imazalil sulfate Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Imazalil58594-72-2EnilconazolelFungalFungicidemPXRmCARabnormalitiesgut microbiota dysbiosishepatic metabolism disorderInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *