2. Vitamin D Related/Nuclear Receptor
  3. VD/VDR
  4. Impurity C of Calcitriol

Impurity C of Calcitriol, Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

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Impurity C of Calcitriol Chemical Structure

Impurity C of Calcitriol Chemical Structure

CAS No. : 86307-44-0

Size Price Stock Quantity
1 mg USD 480 In-stock
5 mg USD 1440 In-stock
10 mg USD 1980 In-stock
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Impurity C of Calcitriol Related Antibodies

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Description

Impurity C of Calcitriol, Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR). IC50 value: Target: vitamin D receptor Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) displays calcemic actions. Calcitriol stimulates intestinal and renal Ca2+ absorption and regulates bone Ca2+ turnover. Calcitriol (1,25-Dihydroxyvitamin D3; Rocaltrol )exhibits antitumor activity; Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.

Molecular Weight

591.78

Formula

C35H49N3O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H](C[C@@H]1O)CC([C@@H]2C=C3[C@@](CC[C@]4([H])[C@@H](CCCC(C)(O)C)C)([H])[C@]4(C)CC[C@@]3([H])N(C(N5C6=CC=CC=C6)=O)N2C5=O)=C1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (84.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6898 mL 8.4491 mL 16.8982 mL
5 mM 0.3380 mL 1.6898 mL 3.3796 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6898 mL 8.4491 mL 16.8982 mL 42.2454 mL
5 mM 0.3380 mL 1.6898 mL 3.3796 mL 8.4491 mL
10 mM 0.1690 mL 0.8449 mL 1.6898 mL 4.2245 mL
15 mM 0.1127 mL 0.5633 mL 1.1265 mL 2.8164 mL
20 mM 0.0845 mL 0.4225 mL 0.8449 mL 2.1123 mL
25 mM 0.0676 mL 0.3380 mL 0.6759 mL 1.6898 mL
30 mM 0.0563 mL 0.2816 mL 0.5633 mL 1.4082 mL
40 mM 0.0422 mL 0.2112 mL 0.4225 mL 1.0561 mL
50 mM 0.0338 mL 0.1690 mL 0.3380 mL 0.8449 mL
60 mM 0.0282 mL 0.1408 mL 0.2816 mL 0.7041 mL
80 mM 0.0211 mL 0.1056 mL 0.2112 mL 0.5281 mL
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Impurity C of Calcitriol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Impurity C of Calcitriol86307-44-0VD/VDRVitamin DVitamin D receptorInhibitorinhibitorinhibit

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