Indoline

Cat. No.: HY-Y0788 Purity: 99.89%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Indoline is a derivative of Indole (HY-W001132). Indoline can used as the basic structure for CD4 mimetic compounds (CD4mcs), which triggers conformational changes of the HIV-1 envelope glycoprotein (Env) in advance, and causes viral inactivation

For research use only. We do not sell to patients.

Indoline Chemical Structure

CAS No. : 496-15-1

Size	Price	Stock	Quantity
25 g	USD 40	In-stock	Estimated Time of Arrival: December 31
100 g	USD 95	Get quote	Estimated Time of Arrival: December 31
> 100 g		Get quote

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HIV HIV-1 HIV-2

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

119.16

Formula

C₈H₉N

CAS No.

496-15-1

Appearance

Liquid

SMILES

C12=C(NCC2)C=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 200 mg/mL (1678.42 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	8.3921 mL	41.9604 mL	83.9208 mL
5 mM	1.6784 mL	8.3921 mL	16.7842 mL
10 mM	0.8392 mL	4.1960 mL	8.3921 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.89%

Select Batch:

Data Sheet (274 KB) SDS (392 KB)

COA (253 KB) HNMR (111 KB) GC (206 KB)

Handling Instructions (2659 KB)

References

[1]. Fritschi CJ, et al., Indoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody-dependent cellular cytotoxicity. Proc Natl Acad Sci U S A. 2023 Mar 28;120(13):e2222073120. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	8.3921 mL	41.9604 mL	83.9208 mL	209.8019 mL
	5 mM	1.6784 mL	8.3921 mL	16.7842 mL	41.9604 mL
	10 mM	0.8392 mL	4.1960 mL	8.3921 mL	20.9802 mL
	15 mM	0.5595 mL	2.7974 mL	5.5947 mL	13.9868 mL
	20 mM	0.4196 mL	2.0980 mL	4.1960 mL	10.4901 mL
	25 mM	0.3357 mL	1.6784 mL	3.3568 mL	8.3921 mL
	30 mM	0.2797 mL	1.3987 mL	2.7974 mL	6.9934 mL
	40 mM	0.2098 mL	1.0490 mL	2.0980 mL	5.2450 mL
	50 mM	0.1678 mL	0.8392 mL	1.6784 mL	4.1960 mL
	60 mM	0.1399 mL	0.6993 mL	1.3987 mL	3.4967 mL
	80 mM	0.1049 mL	0.5245 mL	1.0490 mL	2.6225 mL
	100 mM	0.0839 mL	0.4196 mL	0.8392 mL	2.0980 mL

Indoline Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Indoline496-15-1HIVHuman immunodeficiency virusInhibitorinhibitorinhibit

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