Methyl yellow (Synonyms: Solvent Yellow 2; Dimethyl yellow)

Cat. No.: HY-W025785: FAQs
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Methyl yellow (Solvent Yellow 2) is a pH indicator. Methyl yellow appears red at low pH, and becomes yellow above pH 4.0.

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Methyl yellow Chemical Structure

CAS No. : 60-11-7

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Other Forms of Methyl yellow:

Methyl yellow-d₅ Get quote

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Description	Methyl yellow (Solvent Yellow 2) is a pH indicator. Methyl yellow appears red at low pH, and becomes yellow above pH 4.0^[1].
In Vivo	Methyl yellow can be used in animal modeling to create hepatic tumor models. After administration of Methyl yellow, the levels of dihydroxycholan acid (DHA) decrease in rats that secrete more than 10 mg/100 g body weight of trihydroxycholan acid (THA) daily. The bile volume also increases in the treated rats, and there is a strong correlation between DHA levels and bile volume^[2]. Induction of liver tumor^[2] Background Methyl yellow can degrade cholesterol into bile acids, and specific disorders in bile acid metabolism may lead to the generation of endogenous carcinogens, which can induce liver tumors. Specific Mmodeling Methods Rat: G.G. strain • male • 3-4 months old Administration: 0.06 % of diet • feed • 2-5 months Note (1) Create a fistula in the rat's bile duct, and collect bile from days 2 to 4 after cannulation, discarding the bile from the day before death. (2) The rats were either killed after a period of bile discharge or euthanized with ether. A histological examination was performed on the livers of the euthanized mice. Modeling Indicators Phenotypic observation: Increased bile production and bile drainage lead to bile duct hyperplasia and liver necrosis; the survival time of rats after bile duct cannulation is shortened, and they experience significant weight loss. Correlated Product(s): / Opposite Product(s): / MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	225.29
Formula	C₁₄H₁₅N₃
CAS No.	60-11-7
Appearance	Solid
Color	Light yellow to yellow
SMILES	CN(C)C1=CC=C(/N=N/C2=CC=CC=C2)C=C1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. Nakano N, et, al. An automatic monitor of formaldehyde in air by a monitoring tape method. J Environ Monit. 1999 Jun;1(3):255-8. [Content Brief] [2]. MIRVISH S, et al. Bile acid composition and bile volume in butter yellow fed rats in relation to liver cancer. Br J Cancer. 1960 Jun;14(2):346-61. [Content Brief]

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Keywords:

Methyl yellow60-11-7Solvent Yellow 2 Dimethyl yellowSolvent Yellow2Solvent Yellow-2OthersInhibitorinhibitorinhibit

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Methyl yellow (Synonyms: Solvent Yellow 2; Dimethyl yellow)

Other Forms of Methyl yellow:

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