2. Cell Cycle/DNA Damage
  3. IRE1
  4. IRE1α kinase-IN-2

IRE1α kinase-IN-2 is a potent IRE1α kinase inhibitor, with an EC50 of 0.82 μM. IRE1α kinase-IN-2 inhibits IRE1α kinase autophosphorylation (IC50=3.12 μM). IRE1α kinase-IN-2 inhibits XBP1 mRNA splicing in the WT cell lines.

For research use only. We do not sell to patients.

IRE1α kinase-IN-2 Chemical Structure

IRE1α kinase-IN-2 Chemical Structure

CAS No. : 1414938-21-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 610 In-stock
Solution
10 mM * 1 mL in DMSO USD 610 In-stock
Solid
5 mg USD 550 In-stock
10 mg USD 900 In-stock
25 mg USD 1850 In-stock
50 mg USD 3000 In-stock
100 mg USD 4800 In-stock
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Based on 1 publication(s) in Google Scholar

IRE1α kinase-IN-2 Related Antibodies

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Description

IRE1α kinase-IN-2 is a potent IRE1α kinase inhibitor, with an EC50 of 0.82 μM. IRE1α kinase-IN-2 inhibits IRE1α kinase autophosphorylation (IC50=3.12 μM). IRE1α kinase-IN-2 inhibits XBP1 mRNA splicing in the WT cell lines[1].

In Vitro

IRE1α kinase-IN-2 (compound 3) inhibits XBP1 mRNA splicing, even during ER stress[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IRE1α kinase-IN-2 Related Antibodies
Molecular Weight

504.51

Formula

C27H23F3N6O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=NC=CN2C1=C(C(C3=C4C=CC=C3)=CC=C4NC(NC5=CC(C(F)(F)F)=CC=C5)=O)N=C2C(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (198.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9821 mL 9.9106 mL 19.8212 mL
5 mM 0.3964 mL 1.9821 mL 3.9642 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9821 mL 9.9106 mL 19.8212 mL 49.5530 mL
5 mM 0.3964 mL 1.9821 mL 3.9642 mL 9.9106 mL
10 mM 0.1982 mL 0.9911 mL 1.9821 mL 4.9553 mL
15 mM 0.1321 mL 0.6607 mL 1.3214 mL 3.3035 mL
20 mM 0.0991 mL 0.4955 mL 0.9911 mL 2.4777 mL
25 mM 0.0793 mL 0.3964 mL 0.7928 mL 1.9821 mL
30 mM 0.0661 mL 0.3304 mL 0.6607 mL 1.6518 mL
40 mM 0.0496 mL 0.2478 mL 0.4955 mL 1.2388 mL
50 mM 0.0396 mL 0.1982 mL 0.3964 mL 0.9911 mL
60 mM 0.0330 mL 0.1652 mL 0.3304 mL 0.8259 mL
80 mM 0.0248 mL 0.1239 mL 0.2478 mL 0.6194 mL
100 mM 0.0198 mL 0.0991 mL 0.1982 mL 0.4955 mL
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IRE1α kinase-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IRE1α kinase-IN-21414938-21-8IRE1Inositol requiring enzyme 1oligomerizationXBP1mRNAsplicingERstresscleavageInhibitorinhibitorinhibit

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