2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Isethionic acid

Isethionic acid  (Synonyms: 2-Hydroxyethanesulfonic acid)

Cat. No.: HY-Y0095 Purity: 80.00%
COA Handling Instructions

Molarity Calculator

Isethionic acid (2-Hydroxyethanesulfonic acid) is an organosulfur compound. Isethionic acid is widely distributed in animal species and in a few red algal species. Isethionic acid can be used as an anionic detergent and has anti-settlement activity against Balanus amphitrite.

For research use only. We do not sell to patients.

Isethionic acid Chemical Structure

Isethionic acid Chemical Structure

CAS No. : 107-36-8

Size Price Stock Quantity
Solvent
500 mg（6.34 M * 0.625 mL in Water） USD 50 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Isethionic acid:

Isethionic acid Related Antibodies

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Description

Isethionic acid (2-Hydroxyethanesulfonic acid) is an organosulfur compound. Isethionic acid is widely distributed in animal species and in a few red algal species. Isethionic acid can be used as an anionic detergent and has anti-settlement activity against Balanus amphitrite[1][2].

IC50 & Target

Human Endogenous Metabolite

 

Molecular Weight

126.13

Formula

C2H6O4S
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=S(CCO)(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (792.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (19.82 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (19.82 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 80.00%

COA (246 KB) HNMR (118 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 7.9283 mL 39.6416 mL 79.2833 mL 198.2082 mL
5 mM 1.5857 mL 7.9283 mL 15.8567 mL 39.6416 mL
10 mM 0.7928 mL 3.9642 mL 7.9283 mL 19.8208 mL
15 mM 0.5286 mL 2.6428 mL 5.2856 mL 13.2139 mL
20 mM 0.3964 mL 1.9821 mL 3.9642 mL 9.9104 mL
25 mM 0.3171 mL 1.5857 mL 3.1713 mL 7.9283 mL
30 mM 0.2643 mL 1.3214 mL 2.6428 mL 6.6069 mL
40 mM 0.1982 mL 0.9910 mL 1.9821 mL 4.9552 mL
50 mM 0.1586 mL 0.7928 mL 1.5857 mL 3.9642 mL
60 mM 0.1321 mL 0.6607 mL 1.3214 mL 3.3035 mL
80 mM 0.0991 mL 0.4955 mL 0.9910 mL 2.4776 mL
100 mM 0.0793 mL 0.3964 mL 0.7928 mL 1.9821 mL
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Isethionic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isethionic acid107-36-82-Hydroxyethanesulfonic acidEndogenous MetaboliteOrganosulfuranionicdetergentanti-settlementInhibitorinhibitorinhibit

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