Isograndifoliol 

Isograndifoliol is a selective inhibitor of butyrylcholinesterase (BChE) with an IC₅₀ value of 0.9 μM. And Isograndifoliol moderately inhibits acetylcholinesterase (AChE) with an IC₅₀ value of 342.9 μM. Isograndifoliol also has vasorelaxant effect and anti-tumor effect. Isograndifoliol can be used for research against dementia caused by neurodegenerative diseases^[1][2][3].

Isograndifoliol exhibits dose-dependent vasorelaxant effects on rat aortic rings, preconstricted by KCl or norepinephrine, with EC₅₀ values of 36.36-74.51 μg/mL^[2].
Isograndifoliol exhibits potent activity against HL-60 cells with an IC₅₀ value of 0.33 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

302.41

C₁₉H₂₆O₃

1445475-53-5

CC1=CC2=C(C=C(C1=O)O)[C@](CCCC3(C)C)(CO)[C@H]3CC2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ślusarczyk S, et al. Norditerpenoids with Selective Anti-Cholinesterase Activity from the Roots of Perovskia atriplicifolia Benth. Int J Mol Sci. 2020 Jun 23;21(12):4475.  [Content Brief]

  [2]. Kang J, et al. Isolation and bioactivity of diterpenoids from the roots of Salvia grandifolia. Phytochemistry. 2015 Aug;116:337-348.  [Content Brief]

  [3]. Tsukada H, et al. Two New Diterpenoids from Salvia przewarskii. Nat Prod Commun. 2016 Feb;11(2):159-61.  [Content Brief]