Isorosmanol

Cat. No.: HY-N4191 Purity: 98.08%: FAQs
Data Sheet SDS COA Handling Instructions

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Isorosmanol is an abietane-type diterpene isolated from Rosmarinus officinalis L. aerial parts, with antioxidant, neuroprotective and neurotrophic effects. Isorosmanol inhibits AChE activity and melanin synthesis.

For research use only. We do not sell to patients.

Isorosmanol Chemical Structure

CAS No. : 93780-80-4

Size	Price	Stock	Quantity
1 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 980	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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AChE BChE

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

AChE

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	GI₅₀	19 μM Compound: 4	Cytotoxicity against human A2780 cells after 48 hrs by SRB assay Cytotoxicity against human A2780 cells after 48 hrs by SRB assay	[PMID: 17190465]
A549	IC₅₀	> 60 μM Compound: 12	Cytotoxicity against human A549 cells at lag phase of growth after 48 hrs by MTT assay Cytotoxicity against human A549 cells at lag phase of growth after 48 hrs by MTT assay	[PMID: 19711987]
A549	IC₅₀	46 μM Compound: 12	Cytotoxicity against human A549 cells at exponential phase of growth after 48 hrs by MTT assay Cytotoxicity against human A549 cells at exponential phase of growth after 48 hrs by MTT assay	[PMID: 19711987]
HBL-100	GI₅₀	17 μM Compound: 4	Cytotoxicity against human HBL100 cells after 48 hrs by SRB assay Cytotoxicity against human HBL100 cells after 48 hrs by SRB assay	[PMID: 17190465]
HeLa	IC₅₀	> 60 μM Compound: 12	Cytotoxicity against human HeLa cells at lag phase of growth after 48 hrs by MTT assay Cytotoxicity against human HeLa cells at lag phase of growth after 48 hrs by MTT assay	[PMID: 19711987]
HeLa	IC₅₀	> 60 μM Compound: 12	Cytotoxicity against human HeLa cells at exponential phase of growth after 48 hrs by MTT assay Cytotoxicity against human HeLa cells at exponential phase of growth after 48 hrs by MTT assay	[PMID: 19711987]
MCF7	IC₅₀	36.1 μM Compound: 12	Cytotoxicity against human sMCF7 cells at exponential phase of growth after 48 hrs by MTT assay Cytotoxicity against human sMCF7 cells at exponential phase of growth after 48 hrs by MTT assay	[PMID: 19711987]
MCF7	IC₅₀	54.3 μM Compound: 12	Cytotoxicity against human MCF7 cells at lag phase of growth after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells at lag phase of growth after 48 hrs by MTT assay	[PMID: 19711987]
SW1573	GI₅₀	23 μM Compound: 4	Cytotoxicity against human SW1573 cells after 48 hrs by SRB assay Cytotoxicity against human SW1573 cells after 48 hrs by SRB assay	[PMID: 17190465]
T47D	GI₅₀	> 100 μM Compound: 4	Cytotoxicity against human T47D cells after 48 hrs by SRB assay Cytotoxicity against human T47D cells after 48 hrs by SRB assay	[PMID: 17190465]
Vero	IC₅₀	> 60 μM Compound: 12	Cytotoxicity against african green monkey Vero cells at lag phase of growth after 48 hrs by MTT assay Cytotoxicity against african green monkey Vero cells at lag phase of growth after 48 hrs by MTT assay	[PMID: 19711987]
Vero	IC₅₀	> 60 μM Compound: 12	Cytotoxicity against african green monkey Vero cells at exponential phase of growth after 48 hrs by MTT assay Cytotoxicity against african green monkey Vero cells at exponential phase of growth after 48 hrs by MTT assay	[PMID: 19711987]
WiDr	GI₅₀	> 100 μM Compound: 4	Cytotoxicity against human WiDr cells after 48 hrs by SRB assay Cytotoxicity against human WiDr cells after 48 hrs by SRB assay	[PMID: 17190465]

Molecular Weight

346.42

Formula

C₂₀H₂₆O₅

CAS No.

93780-80-4

Appearance

Solid

SMILES

O=C1O[C@]2([H])C3=C(C(O)=C(O)C(C(C)C)=C3)[C@@]41CCCC(C)(C)[C@]4([H])[C@H]2O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (288.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8867 mL	14.4333 mL	28.8667 mL
5 mM	0.5773 mL	2.8867 mL	5.7733 mL
10 mM	0.2887 mL	1.4433 mL	2.8867 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.08%

Select Batch:

Data Sheet (277 KB) SDS (251 KB)

COA (255 KB) HNMR (266 KB) CNMR (183 KB) RP-HPLC (156 KB)

Handling Instructions (2659 KB)

References

[1]. Miura K, et al. Antioxidant activity of chemical components from sage (Salvia officinalis L.) and thyme (Thymus vulgaris L.) measured by the oil stability index method. J Agric Food Chem. 2002 Mar 27;50(7):1845-51. [Content Brief]

[2]. Park SY, et al. Neuroprotective and neurotrophic effects of isorosmanol. Z Naturforsch C. 2009 May-Jun;64(5-6):395-8. [Content Brief]

[3]. Sallam A, et al. Acetylcholine esterase inhibitors and melanin synthesis inhibitors from Salvia officinalis. Phytomedicine. 2016 Sep 15;23(10):1005-11. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8867 mL	14.4333 mL	28.8667 mL	72.1667 mL
	5 mM	0.5773 mL	2.8867 mL	5.7733 mL	14.4333 mL
	10 mM	0.2887 mL	1.4433 mL	2.8867 mL	7.2167 mL
	15 mM	0.1924 mL	0.9622 mL	1.9244 mL	4.8111 mL
	20 mM	0.1443 mL	0.7217 mL	1.4433 mL	3.6083 mL
	25 mM	0.1155 mL	0.5773 mL	1.1547 mL	2.8867 mL
	30 mM	0.0962 mL	0.4811 mL	0.9622 mL	2.4056 mL
	40 mM	0.0722 mL	0.3608 mL	0.7217 mL	1.8042 mL
	50 mM	0.0577 mL	0.2887 mL	0.5773 mL	1.4433 mL
	60 mM	0.0481 mL	0.2406 mL	0.4811 mL	1.2028 mL
	80 mM	0.0361 mL	0.1804 mL	0.3608 mL	0.9021 mL
	100 mM	0.0289 mL	0.1443 mL	0.2887 mL	0.7217 mL

Isorosmanol Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isorosmanol93780-80-4Cholinesterase (ChE)Inhibitorinhibitorinhibit

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Isorosmanol

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Isorosmanol Related Antibodies

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Complete Stock Solution Preparation Table

Isorosmanol Related Classifications

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