2. Apoptosis
  3. TNF Receptor
  4. IW927

IW927 is a potent small molecule antagonist that blocks the binding of TNF-α to TNFRc1 with an IC50 value of 50 nM and disrupts TNFα-induced IκB phosphorylation with an IC50 value of 600 nM.

For research use only. We do not sell to patients.

IW927 Chemical Structure

IW927 Chemical Structure

CAS No. : 389142-48-7

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5 mg USD 390 In-stock
10 mg USD 625 In-stock
25 mg USD 1312 In-stock
50 mg USD 2100 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

IW927 Related Antibodies

Top Publications Citing Use of Products

View All TNF Receptor Isoform Specific Products:

View All Isoforms
TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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  • Purity & Documentation

  • References

  • Customer Review

Description

IW927 is a potent small molecule antagonist that blocks the binding of TNF-α to TNFRc1 with an IC50 value of 50 nM and disrupts TNFα-induced IκB phosphorylation with an IC50 value of 600 nM[1].

Molecular Weight

441.57

Formula

C22H23N3O3S2
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

O=C(C1=CC2=C(C=C(S2)C3=CC=CC(OC)=C3)N1C4=S)N4CCCN5CCOCC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (22.65 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2646 mL 11.3232 mL 22.6465 mL
5 mM 0.4529 mL 2.2646 mL 4.5293 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.04%

SDS (251 KB)

COA (247 KB) HNMR (120 KB) RP-HPLC (140 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2646 mL 11.3232 mL 22.6465 mL 56.6162 mL
5 mM 0.4529 mL 2.2646 mL 4.5293 mL 11.3232 mL
10 mM 0.2265 mL 1.1323 mL 2.2646 mL 5.6616 mL
15 mM 0.1510 mL 0.7549 mL 1.5098 mL 3.7744 mL
20 mM 0.1132 mL 0.5662 mL 1.1323 mL 2.8308 mL
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IW927 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IW927389142-48-7IW 927IW-927TNF ReceptorTumor Necrosis Factor ReceptorTNFRTNF-αTNFRc1IκB phosphorylationInhibitorinhibitorinhibit

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