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  4. Janelia Fluor® 646, Maleimide

Janelia Fluor® 646, Maleimide  (Synonyms: JF646, Maleimide)

Cat. No.: HY-131029 Purity: ≥95.0%
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Handling Instructions Technical Support

Janelia Fluor® 646, Maleimide (JF646, Maleimide) is a red fluorescent dye that contains a maleimide group. JF646, Maleimide can be used in cellular imaging. Janelia Fluor® products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

For research use only. We do not sell to patients.

Janelia Fluor® 646, Maleimide Chemical Structure

Janelia Fluor® 646, Maleimide Chemical Structure

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Janelia Fluor® 646, Maleimide:

Janelia Fluor® 646, Maleimide Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Janelia Fluor® 646, Maleimide (JF646, Maleimide) is a red fluorescent dye that contains a maleimide group. JF646, Maleimide can be used in cellular imaging[1][2]. Janelia Fluor® products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

In Vitro

λmax (nm)=646; λem (nm)=664[1].
JF646 can serve as a ligand for self-labeling tag (such as HaloTag)[1].
JF646, Maleimide is modified by JF646. JF646, a red fluorescent dye, is photostable, membrane-permeable, has a high extinction coefficient[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Janelia Fluor® 646, Maleimide Related Antibodies
Molecular Weight

618.75

Formula

C35H34N4O5Si
Appearance

Solid

Color

Light green to green

Emission (Em)

646
Excitation (Ex)

605
SMILES

O=C(C1=CC=C(C(C(C2=CC=C(C=C2[Si]3(C)C)N4CCC4)=C(C3=C/5)C=CC5=[N+]6CCC/6)=C1)C([O-])=O)NCCN7C(C=CC7=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (80.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6162 mL 8.0808 mL 16.1616 mL
5 mM 0.3232 mL 1.6162 mL 3.2323 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6162 mL 8.0808 mL 16.1616 mL 40.4040 mL
5 mM 0.3232 mL 1.6162 mL 3.2323 mL 8.0808 mL
10 mM 0.1616 mL 0.8081 mL 1.6162 mL 4.0404 mL
15 mM 0.1077 mL 0.5387 mL 1.0774 mL 2.6936 mL
20 mM 0.0808 mL 0.4040 mL 0.8081 mL 2.0202 mL
25 mM 0.0646 mL 0.3232 mL 0.6465 mL 1.6162 mL
30 mM 0.0539 mL 0.2694 mL 0.5387 mL 1.3468 mL
40 mM 0.0404 mL 0.2020 mL 0.4040 mL 1.0101 mL
50 mM 0.0323 mL 0.1616 mL 0.3232 mL 0.8081 mL
60 mM 0.0269 mL 0.1347 mL 0.2694 mL 0.6734 mL
80 mM 0.0202 mL 0.1010 mL 0.2020 mL 0.5051 mL
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Janelia Fluor® 646, Maleimide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Janelia Fluor® 646, MaleimideJF646, MaleimideFluorescent DyefluorescentligandimagingSTEDSRMInhibitorinhibitorinhibit

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