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JH-VIII-49 is a potent and selective CDK8 inhibitor with excellent biological activity. The synthesis of JH-VIII-49 is simplified to eight steps with an overall yield of 33%, making it suitable for large-scale production. JH-VIII-49 promotes CDK8 inhibition through its steroid skeleton design. JH-VIII-49 provides a basis for the subsequent development of more complex bivalent small molecule degraders.

For research use only. We do not sell to patients.

JH-VIII-49 Chemical Structure

JH-VIII-49 Chemical Structure

CAS No. : 2209084-73-9

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JH-VIII-49 Related Antibodies

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Description

JH-VIII-49 is a potent and selective CDK8 inhibitor with excellent biological activity. The synthesis of JH-VIII-49 is simplified to eight steps with an overall yield of 33%, making it suitable for large-scale production. JH-VIII-49 promotes CDK8 inhibition through its steroid skeleton design. JH-VIII-49 provides a basis for the subsequent development of more complex bivalent small molecule degraders[1].

Molecular Weight

428.65

Formula

C30H40N2
CAS No.
SMILES

C[C@@]12[C@](CC[C@@H]2C3=CC4=C(C=CN=C4)C=C3)([H])[C@@]5([H])[C@]([C@@]6(C(C[C@H](CC6)N(C)C)=CC5)C)([H])CC1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JH-VIII-49 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JH-VIII-492209084-73-9OthersInhibitorinhibitorinhibit

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